ENSG00000149636


Homo sapiens

Features
Gene ID: ENSG00000149636
  
Biological name :DSN1
  
Synonyms : DSN1 / DSN1 homolog, MIS12 kinetochore complex component / Q9H410
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.23
Gene start: 36751791
Gene end: 36773818
  
Corresponding Affymetrix probe sets: 219512_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404463
Ensembl peptide - ENSP00000362839
Ensembl peptide - ENSP00000362845
Ensembl peptide - ENSP00000362855
Ensembl peptide - ENSP00000389810
Ensembl peptide - ENSP00000395760
Ensembl peptide - ENSP00000399654
NCBI entrez gene - 79980     See in Manteia.
OMIM - 609175
RefSeq - XM_017028072
RefSeq - NM_001145315
RefSeq - NM_001145316
RefSeq - NM_001145317
RefSeq - NM_001145318
RefSeq - NM_024918
RefSeq - XM_006723876
RefSeq - XM_017028070
RefSeq - XM_017028071
RefSeq Peptide - NP_079194
RefSeq Peptide - NP_001138787
RefSeq Peptide - NP_001138788
RefSeq Peptide - NP_001138789
RefSeq Peptide - NP_001138790
swissprot - Q5JW53
swissprot - Q5JW54
swissprot - Q5JW57
swissprot - Q9H410
Ensembl - ENSG00000149636
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dsn1ENSDARG00000089922Danio rerio
 Dsn1ENSMUSG00000027635Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013218  Kinetochore-associated protein Dsn1/Mis13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051456 attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation IBA
 cellular_componentGO:0000444 MIS12/MIND type complex IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IDA
 cellular_componentGO:0000818 nuclear MIS12/MIND complex IBA
 cellular_componentGO:0000922 spindle pole IBA
 cellular_componentGO:0000941 condensed nuclear chromosome inner kinetochore IBA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Neutrophil degranulation
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117697 NSL1 / Q96IY1 / NSL1, MIS12 kinetochore complex component  / complex
 ENSG00000143228 NUF2 / Q9BZD4 / NUF2, NDC80 kinetochore complex component  / complex
 ENSG00000161888 SPC24 / Q8NBT2 / SPC24, NDC80 kinetochore complex component  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000167842 MIS12 / Q9H081 / MIS12, kinetochore complex component  / complex
 ENSG00000160783 PMF1 / Q6P1K2 / polyamine modulated factor 1  / complex
 ENSG00000080986 NDC80 / O14777 / NDC80, kinetochore complex component  / complex
 ENSG00000152253 SPC25 / Q9HBM1 / SPC25, NDC80 kinetochore complex component  / complex






 

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