ENSG00000161888


Homo sapiens

Features
Gene ID: ENSG00000161888
  
Biological name :SPC24
  
Synonyms : Q8NBT2 / SPC24 / SPC24, NDC80 kinetochore complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.2
Gene start: 11131520
Gene end: 11155808
  
Corresponding Affymetrix probe sets: 217183_at (Human Genome U133 Plus 2.0 Array)   235572_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468366
Ensembl peptide - ENSP00000466688
Ensembl peptide - ENSP00000468818
Ensembl peptide - ENSP00000397131
Ensembl peptide - ENSP00000465075
Ensembl peptide - ENSP00000465167
Ensembl peptide - ENSP00000465335
NCBI entrez gene - 147841     See in Manteia.
OMIM - 609394
RefSeq - XM_011527702
RefSeq - NM_001317031
RefSeq - NM_001317032
RefSeq - NM_001317033
RefSeq - NM_182513
RefSeq - XM_005259753
RefSeq Peptide - NP_001303962
RefSeq Peptide - NP_872319
RefSeq Peptide - NP_001303960
RefSeq Peptide - NP_001303961
swissprot - K7ERQ7
swissprot - K7ESQ2
swissprot - K7EJH0
swissprot - K7EJV2
swissprot - K7EMX1
swissprot - Q8NBT2
swissprot - A0A0A0MSN0
Ensembl - ENSG00000161888
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spc24ENSDARG00000093622Danio rerio
 Spc24ENSMUSG00000074476Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013252  Kinetochore-Ndc80 subunit Spc24


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031262 Ndc80 complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000160783 PMF1 / Q6P1K2 / polyamine modulated factor 1  / complex
 ENSG00000149636 DSN1 / Q9H410 / DSN1 homolog, MIS12 kinetochore complex component  / complex
 ENSG00000117697 NSL1 / Q96IY1 / NSL1, MIS12 kinetochore complex component  / complex
 ENSG00000167842 MIS12 / Q9H081 / MIS12, kinetochore complex component  / complex
 ENSG00000143228 NUF2 / Q9BZD4 / NUF2, NDC80 kinetochore complex component  / complex
 ENSG00000152253 SPC25 / Q9HBM1 / SPC25, NDC80 kinetochore complex component  / complex
 ENSG00000080986 NDC80 / O14777 / NDC80, kinetochore complex component  / complex






 

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