ENSG00000117697


Homo sapiens

Features
Gene ID: ENSG00000117697
  
Biological name :NSL1
  
Synonyms : NSL1 / NSL1, MIS12 kinetochore complex component / Q96IY1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.3
Gene start: 212726153
Gene end: 212791782
  
Corresponding Affymetrix probe sets: 209483_s_at (Human Genome U133 Plus 2.0 Array)   209484_s_at (Human Genome U133 Plus 2.0 Array)   230592_at (Human Genome U133 Plus 2.0 Array)   235799_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355943
Ensembl peptide - ENSP00000355944
Ensembl peptide - ENSP00000355945
Ensembl peptide - ENSP00000486783
NCBI entrez gene - 25936     See in Manteia.
OMIM - 609174
RefSeq - XM_017000969
RefSeq - NM_001042549
RefSeq - NM_001297736
RefSeq - NM_001297737
RefSeq - NM_001297739
RefSeq - NM_015471
RefSeq - XM_017000968
RefSeq Peptide - NP_001284666
RefSeq Peptide - NP_001284668
RefSeq Peptide - NP_056286
RefSeq Peptide - NP_001036014
RefSeq Peptide - NP_001284665
swissprot - Q5SY76
swissprot - Q96IY1
swissprot - Q53FM2
swissprot - Q5SY74
Ensembl - ENSG00000117697
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsl1ENSDARG00000024471Danio rerio
 NSL1ENSGALG00000009814Gallus gallus
 Nsl1ENSMUSG00000062510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013950  Kinetochore Mis14/Nsl1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000444 MIS12/MIND type complex IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149636 DSN1 / Q9H410 / DSN1 homolog, MIS12 kinetochore complex component  / complex
 ENSG00000161888 SPC24 / Q8NBT2 / SPC24, NDC80 kinetochore complex component  / complex
 ENSG00000143228 NUF2 / Q9BZD4 / NUF2, NDC80 kinetochore complex component  / complex
 ENSG00000167842 MIS12 / Q9H081 / MIS12, kinetochore complex component  / complex
 ENSG00000137812 KNL1 / Q8NG31 / kinetochore scaffold 1  / complex
 ENSG00000080986 NDC80 / O14777 / NDC80, kinetochore complex component  / complex
 ENSG00000152253 SPC25 / Q9HBM1 / SPC25, NDC80 kinetochore complex component  / complex
 ENSG00000160783 PMF1 / Q6P1K2 / polyamine modulated factor 1  / complex






 

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