ENSMUSG00000031715


Mus musculus

Features
Gene ID: ENSMUSG00000031715
  
Biological name :Smarca5
  
Synonyms : Q91ZW3 / Smarca5 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
  
Possible biological names infered from orthology : O60264
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 80698507
Gene end: 80739497
  
Corresponding Affymetrix probe sets: 10510142 (MoGene1.0st)   10510176 (MoGene1.0st)   10518361 (MoGene1.0st)   10579915 (MoGene1.0st)   1424205_at (Mouse Genome 430 2.0 Array)   1424206_at (Mouse Genome 430 2.0 Array)   1424207_at (Mouse Genome 430 2.0 Array)   1440048_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044361
NCBI entrez gene - 93762     See in Manteia.
MGI - MGI:1935129
RefSeq - NM_053124
RefSeq Peptide - NP_444354
swissprot - Q91ZW3
Ensembl - ENSMUSG00000031715
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SMARCA5ENSGALG00000009913Gallus gallus
 O60264ENSG00000153147Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PGB8 / Smarca1 / Mus musculus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (Smarca1), transcript variant 3, mRNA. / P28370* / SWI/SNF ...ENSMUSG0000003109979
Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*ENSMUSG0000002808927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001005  SANT/Myb domain
 IPR001650  Helicase, C-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR015194  ISWI, HAND domain
 IPR015195  SLIDE domain
 IPR017884  SANT domain
 IPR020838  DBINO domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029915  ISWI family
 IPR036306  ISWI, HAND domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA IDA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly IDA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006338 chromatin remodeling ISO
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0016584 nucleosome positioning IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005677 chromatin silencing complex IDA
 cellular_componentGO:0016589 NURF complex ISO
 cellular_componentGO:0031010 ISWI-type complex IPI
 cellular_componentGO:0031213 RSF complex IEA
 cellular_componentGO:0043596 nuclear replication fork IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000421 mottled coat "coat has spots, streaks, and/or blotches of a different color" [J:17194]
Show

Allelic Composition: Avy/A,Dnmt1MommeD2/Dnmt1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Avy/A,Dnmt1MommeD2/Dnmt1+
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012119 increased trophectoderm apoptosis "increase in the number of trophectoderm cells undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012120 trophectoderm cell degeneration "a retrogressive impairment of function or destruction of trophectoderm cells" [MGI:anna]
Show

Allelic Composition: Hoxb8tm1Omm/Hoxb8+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027326 Knl1 / Q66JQ7 / Kinetochore scaffold 1 / Q8NG31*  / complex
 ENSMUSG00000002748 Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000029177 Cenpa / O35216 / Histone H3-like centromeric protein A / P49450* / centromere protein A*  / complex
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / reaction
 ENSMUSG00000035623 Rsf1 / remodeling and spacing factor 1 / Q96T23*  / complex






 

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