ENSMUSG00000031099


Mus musculus

Features
Gene ID: ENSMUSG00000031099
  
Biological name :Smarca1
  
Synonyms : Mus musculus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (Smarca1), transcript variant 3, mRNA. / Q6PGB8 / Smarca1
  
Possible biological names infered from orthology : P28370 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A5
Gene start: 47809368
Gene end: 47892974
  
Corresponding Affymetrix probe sets: 10604347 (MoGene1.0st)   1460292_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135570
Ensembl peptide - ENSMUSP00000076769
Ensembl peptide - ENSMUSP00000086366
Ensembl peptide - ENSMUSP00000099138
Ensembl peptide - ENSMUSP00000114296
Ensembl peptide - ENSMUSP00000116209
NCBI entrez gene - 93761     See in Manteia.
MGI - MGI:1935127
RefSeq - XM_017318646
RefSeq - NM_001290708
RefSeq - NM_001358618
RefSeq - NM_001358619
RefSeq - NM_053123
RefSeq - XM_006541563
RefSeq Peptide - NP_001277637
RefSeq Peptide - NP_001345547
RefSeq Peptide - NP_001345548
RefSeq Peptide - NP_444353
swissprot - F6QS43
swissprot - Q6PGB8
swissprot - Q8BS67
swissprot - F6Z6F4
Ensembl - ENSMUSG00000031099
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smarca1ENSDARG00000012776Danio rerio
 SMARCA1ENSGALG00000008431Gallus gallus
 P28370ENSG00000102038Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91ZW3 / Smarca5 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 / O60264*ENSMUSG0000003171578
Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*ENSMUSG0000002808927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001005  SANT/Myb domain
 IPR001650  Helicase, C-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR015194  ISWI, HAND domain
 IPR015195  SLIDE domain
 IPR017884  SANT domain
 IPR020838  DBINO domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029915  ISWI family
 IPR036306  ISWI, HAND domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000733 DNA strand renaturation IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling ISS
 biological_processGO:0006351 transcription, DNA-templated ISS
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0007420 brain development ISS
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0043044 ATP-dependent chromatin remodeling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:2000177 regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0016589 NURF complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0090537 CERF complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity ISS
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0036310 annealing helicase activity ISS
 molecular_functionGO:0070615 nucleosome-dependent ATPase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nos3tm1Unc/Nos3+
Genetic Background: B6.129P2-Nos3tm1Unc/J

Allelic Composition: Smarca1tm1.1Pick/Y
Genetic Background: involves: 129S4/SvJae * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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