ENSMUSG00000035623


Mus musculus

Features
Gene ID: ENSMUSG00000035623
  
Biological name :Rsf1
  
Synonyms : remodeling and spacing factor 1 / Rsf1
  
Possible biological names infered from orthology : Q96T23
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 97579889
Gene end: 97692778
  
Corresponding Affymetrix probe sets: 10555089 (MoGene1.0st)   1438062_at (Mouse Genome 430 2.0 Array)   1438735_at (Mouse Genome 430 2.0 Array)   1453381_at (Mouse Genome 430 2.0 Array)   1457751_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102771
Ensembl peptide - ENSMUSP00000145905
Ensembl peptide - ENSMUSP00000145808
Ensembl peptide - ENSMUSP00000145663
NCBI entrez gene - 233532     See in Manteia.
MGI - MGI:2682305
RefSeq - NM_001081267
RefSeq Peptide - NP_001074736
swissprot - E9PWW9
swissprot - A0A0U1RNQ5
swissprot - A0A0U1RPA7
swissprot - A0A0U1RP31
Ensembl - ENSMUSG00000035623
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rsf1b.1ENSDARG00000093503Danio rerio
 rsf1b.1ENSDARG00000068640Danio rerio
 RSF1ENSGALG00000039068Gallus gallus
 RSF1ENSG00000048649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger
 IPR028938  Remodeling and spacing factor 1
 IPR028942  WHIM1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly ISO
 biological_processGO:0006338 chromatin remodeling ISO
 biological_processGO:0006352 DNA-templated transcription, initiation ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016584 nucleosome positioning ISO
 biological_processGO:0043392 negative regulation of DNA binding ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0050434 positive regulation of viral transcription ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0031213 RSF complex ISO
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deposition of new CENPA-containing nucleosomes at the centromere


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031715 Q91ZW3 / Smarca5 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 / O60264*  / complex
 ENSMUSG00000029177 Cenpa / O35216 / Histone H3-like centromeric protein A / P49450* / centromere protein A*  / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex
 ENSMUSG00000027326 Knl1 / Q66JQ7 / Kinetochore scaffold 1 / Q8NG31*  / complex






 

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