ENSG00000134014


Homo sapiens

Features
Gene ID: ENSG00000134014
  
Biological name :ELP3
  
Synonyms : elongator acetyltransferase complex subunit 3 / ELP3 / Q9H9T3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.1
Gene start: 28089673
Gene end: 28191156
  
Corresponding Affymetrix probe sets: 221094_s_at (Human Genome U133 Plus 2.0 Array)   227075_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428532
Ensembl peptide - ENSP00000445558
Ensembl peptide - ENSP00000430942
Ensembl peptide - ENSP00000430253
Ensembl peptide - ENSP00000429573
Ensembl peptide - ENSP00000429465
Ensembl peptide - ENSP00000429446
Ensembl peptide - ENSP00000429248
Ensembl peptide - ENSP00000429180
Ensembl peptide - ENSP00000256398
Ensembl peptide - ENSP00000369711
Ensembl peptide - ENSP00000427833
Ensembl peptide - ENSP00000428357
Ensembl peptide - ENSP00000428449
NCBI entrez gene - 55140     See in Manteia.
OMIM - 612722
RefSeq - XM_017013604
RefSeq - NM_001284220
RefSeq - NM_001284222
RefSeq - NM_001284224
RefSeq - NM_001284225
RefSeq - NM_001284226
RefSeq - NM_018091
RefSeq - XM_006716354
RefSeq Peptide - NP_060561
RefSeq Peptide - NP_001271153
RefSeq Peptide - NP_001271154
RefSeq Peptide - NP_001271149
RefSeq Peptide - NP_001271151
RefSeq Peptide - NP_001271155
swissprot - E5RG26
swissprot - B4DKA4
swissprot - E5RIU1
swissprot - H0YC54
swissprot - H0YAP7
swissprot - Q9H9T3
swissprot - E5RIZ7
swissprot - E5RIC0
swissprot - E5RHY2
swissprot - E5RHR2
Ensembl - ENSG00000134014
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elp3ENSDARG00000042005Danio rerio
 ELP3ENSGALG00000016624Gallus gallus
 Elp3ENSMUSG00000022031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013785  Aldolase-type TIM barrel
 IPR016181  Acyl-CoA N-acyltransferase
 IPR032432  Radical SAM, C-terminal extension
 IPR034687  Elongator complex protein 3-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007417 central nervous system development ISS
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0043966 histone H3 acetylation IDA
 biological_processGO:0043967 histone H4 acetylation IDA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008023 transcription elongation factor complex IDA
 cellular_componentGO:0033588 Elongator holoenzyme complex IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0008607 phosphorylase kinase regulator activity IDA
 molecular_functionGO:0010484 H3 histone acetyltransferase activity IDA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000109911 ELP4 / Q96EB1 / elongator acetyltransferase complex subunit 4  / complex
 ENSG00000170291 ELP5 / Q8TE02 / elongator acetyltransferase complex subunit 5  / complex
 ENSG00000070061 ELP1 / O95163 / elongator complex protein 1  / complex
 ENSG00000134759 ELP2 / Q6IA86 / elongator acetyltransferase complex subunit 2  / complex
 ENSG00000163832 ELP6 / Q0PNE2 / elongator acetyltransferase complex subunit 6  / complex






 

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