ENSMUSG00000022031


Mus musculus

Features
Gene ID: ENSMUSG00000022031
  
Biological name :Elp3
  
Synonyms : Elongator complex protein 3 / Elp3 / Q9CZX0
  
Possible biological names infered from orthology : elongator acetyltransferase complex subunit 3 / Q9H9T3
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 65530449
Gene end: 65593075
  
Corresponding Affymetrix probe sets: 10420860 (MoGene1.0st)   1426643_at (Mouse Genome 430 2.0 Array)   1436762_x_at (Mouse Genome 430 2.0 Array)   1437338_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153462
Ensembl peptide - ENSMUSP00000022609
Ensembl peptide - ENSMUSP00000153177
NCBI entrez gene - 74195     See in Manteia.
MGI - MGI:1921445
RefSeq - NM_001253812
RefSeq - NM_028811
RefSeq Peptide - NP_001240741
RefSeq Peptide - NP_083087
swissprot - A0A286YDB8
swissprot - Q9CZX0
Ensembl - ENSMUSG00000022031
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elp3ENSDARG00000042005Danio rerio
 ELP3ENSGALG00000016624Gallus gallus
 ELP3ENSG00000134014Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000182  GNAT domain
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013785  Aldolase-type TIM barrel
 IPR016181  Acyl-CoA N-acyltransferase
 IPR032432  Radical SAM, C-terminal extension
 IPR034687  Elongator complex protein 3-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0043966 histone H3 acetylation IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0008023 transcription elongation factor complex IEA
 cellular_componentGO:0033588 Elongator holoenzyme complex IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0008080 N-acetyltransferase activity IEA
 molecular_functionGO:0008607 phosphorylase kinase regulator activity IEA
 molecular_functionGO:0010484 H3 histone acetyltransferase activity IEA
 molecular_functionGO:0010485 H4 histone acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi,Mus81tm1Chmg/Mus81tm1Chmg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N * FVB/N

Allelic Composition: ApcMin/Apc+,Elp3tm1.1Tac/Elp3tm1.1Tac,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0003380 abnormal intestine regeneration "deviation from the normal ability of the intestine to regenerate healthy tissue following injury" [J:93428, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fan1tm1d(KOMP)Wtsi/Fan1tm1d(KOMP)Wtsi,Mus81tm1Chmg/Mus81tm1Chmg
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N * FVB/N

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: ApcMin/Apc+,Elp3tm1.1Tac/Elp3tm1.1Tac,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

 MP:0010156 abnormal small intestinal crypt cell physiology "altered function of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Elp3tm1.1Tac/Elp3tm1.1Tac,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac

 MP:0012434 decreased intestinal adenoma incidence "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]
Show

Allelic Composition: ApcMin/Apc+,Elp3tm1.1Tac/Elp3tm1.1Tac,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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