ENSG00000158161


Homo sapiens

Features
Gene ID: ENSG00000158161
  
Biological name :EYA3
  
Synonyms : EYA3 / EYA transcriptional coactivator and phosphatase 3 / Q99504
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p35.3
Gene start: 27970344
Gene end: 28088696
  
Corresponding Affymetrix probe sets: 1552314_a_at (Human Genome U133 Plus 2.0 Array)   1554844_at (Human Genome U133 Plus 2.0 Array)   206379_at (Human Genome U133 Plus 2.0 Array)   226170_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362970
Ensembl peptide - ENSP00000362978
Ensembl peptide - ENSP00000405587
Ensembl peptide - ENSP00000442558
Ensembl peptide - ENSP00000362971
NCBI entrez gene - 2140     See in Manteia.
OMIM - 601655
RefSeq - XM_017000659
RefSeq - NM_001282560
RefSeq - NM_001282561
RefSeq - NM_001282562
RefSeq - NM_001990
RefSeq - XM_017000653
RefSeq - XM_017000654
RefSeq - XM_017000655
RefSeq - XM_017000656
RefSeq - XM_017000657
RefSeq - XM_017000658
RefSeq - XM_006710449
RefSeq - XM_011540999
RefSeq - XM_011541001
RefSeq - XM_011541003
RefSeq - XM_011541004
RefSeq - XM_017000652
RefSeq Peptide - NP_001269489
RefSeq Peptide - NP_001269490
RefSeq Peptide - NP_001269491
RefSeq Peptide - NP_001981
swissprot - Q99504
swissprot - B1APR7
Ensembl - ENSG00000158161
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eya3ENSDARG00000036100Danio rerio
 EYA3ENSGALG00000000777Gallus gallus
 Eya3ENSMUSG00000028886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EYA4 / O95677 / EYA transcriptional coactivator and phosphatase 4ENSG0000011231941
EYA1 / Q99502 / EYA transcriptional coactivator and phosphatase 1ENSG0000010431341
EYA2 / O00167 / EYA transcriptional coactivator and phosphatase 2ENSG0000006465536


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR023214  HAD superfamily
 IPR028472  Eyes absent family
 IPR028479  Eyes absent homologue 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007601 visual perception TAS
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0010212 response to ionizing radiation IDA
 biological_processGO:0016576 histone dephosphorylation IDA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / reaction
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr