ENSDARG00000036100


Danio rerio

Features
Gene ID: ENSDARG00000036100
  
Biological name :eya3
  
Synonyms : eya3 / EYA transcriptional coactivator and phosphatase 3
  
Possible biological names infered from orthology : Eyes absent homolog 3 / P97480 / Q99504
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 24891747
Gene end: 24917208
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000156062
Ensembl peptide - ENSDARP00000049839
Ensembl peptide - ENSDARP00000118433
NCBI entrez gene - 571385     See in Manteia.
RefSeq - XM_005170064
RefSeq - XM_005170065
RefSeq - NM_001080052
RefSeq Peptide - NP_001073521
swissprot - F1R5X1
swissprot - A3KQ54
ZFIN ID - ZDB-GENE-060503-864
Ensembl - ENSDARG00000036100
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EYA3ENSGALG00000000777Gallus gallus
 EYA3ENSG00000158161Homo sapiens
 Eya3ENSMUSG00000028886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eya4 / EYA transcriptional coactivator and phosphatase 4 / O95677* / Q9Z191* / Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA.*ENSDARG0000001239737
eya1 / EYA transcriptional coactivator and phosphatase 1 / P97767* / Q99502* / Eyes absent homolog 1 *ENSDARG0000001425936
eya2 / EYA transcriptional coactivator and phosphatase 2 / O00167* / O08575* / Eyes absent homolog 2 *ENSDARG0000001898433


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028472  Eyes absent family
 IPR028479  Eyes absent homologue 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016576 histone dephosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0048856 anatomical structure development IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / reaction






 

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