ENSDARG00000018984


Danio rerio

Features
Gene ID: ENSDARG00000018984
  
Biological name :eya2
  
Synonyms : eya2 / EYA transcriptional coactivator and phosphatase 2
  
Possible biological names infered from orthology : Eyes absent homolog 2 / O00167 / O08575
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 55909795
Gene end: 55997350
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000006502
Ensembl peptide - ENSDARP00000129441
NCBI entrez gene - 447819     See in Manteia.
RefSeq - NM_001004558
RefSeq Peptide - NP_001004558
swissprot - Q66HX1
swissprot - X1WGT2
ZFIN ID - ZDB-GENE-040912-24
Ensembl - ENSDARG00000018984
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000042523Gallus gallus
 EYA2ENSGALG00000004508Gallus gallus
 EYA2ENSG00000064655Homo sapiens
 Eya2ENSMUSG00000017897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eya1 / EYA transcriptional coactivator and phosphatase 1 / P97767* / Q99502* / Eyes absent homolog 1 *ENSDARG0000001425963
eya4 / EYA transcriptional coactivator and phosphatase 4 / O95677* / Q9Z191* / Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA.*ENSDARG0000001239756
eya3 / EYA transcriptional coactivator and phosphatase 3 / P97480* / Q99504* / Eyes absent homolog 3 *ENSDARG0000003610042


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028472  Eyes absent family
 IPR028473  Eyes absent homologue 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014706 striated muscle tissue development IEA
 biological_processGO:0016576 histone dephosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction






 

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