ENSMUSG00000017897


Mus musculus

Features
Gene ID: ENSMUSG00000017897
  
Biological name :Eya2
  
Synonyms : Eya2 / Eyes absent homolog 2 / O08575
  
Possible biological names infered from orthology : EYA transcriptional coactivator and phosphatase 2 / O00167
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 165595032
Gene end: 165771727
  
Corresponding Affymetrix probe sets: 10478698 (MoGene1.0st)   1424127_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066244
Ensembl peptide - ENSMUSP00000085455
NCBI entrez gene - 14049     See in Manteia.
MGI - MGI:109341
RefSeq - XM_006498739
RefSeq - NM_001271962
RefSeq - NM_001271963
RefSeq - NM_010165
RefSeq Peptide - NP_001258892
RefSeq Peptide - NP_034295
RefSeq Peptide - NP_001258891
swissprot - O08575
Ensembl - ENSMUSG00000017897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eya2ENSDARG00000018984Danio rerio
 ENSGALG00000042523Gallus gallus
 EYA2ENSGALG00000004508Gallus gallus
 EYA2ENSG00000064655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eya1 / P97767 / Eyes absent homolog 1 / Q99502* / EYA transcriptional coactivator and phosphatase 1*ENSMUSG0000002593264
Eya4 / Q9Z191 / Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA. / O95677* / EYA transcriptional coactivator and phosphatase 4*ENSMUSG0000001046158
Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*ENSMUSG0000002888639


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028472  Eyes absent family
 IPR028473  Eyes absent homologue 2
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014706 striated muscle tissue development IGI
 biological_processGO:0016576 histone dephosphorylation ISO
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

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