ENSMUSG00000010461


Mus musculus

Features
Gene ID: ENSMUSG00000010461
  
Biological name :Eya4
  
Synonyms : Eya4 / Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA. / Q9Z191
  
Possible biological names infered from orthology : EYA transcriptional coactivator and phosphatase 4 / O95677
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A3
Gene start: 23102963
Gene end: 23350786
  
Corresponding Affymetrix probe sets: 10368243 (MoGene1.0st)   1432461_at (Mouse Genome 430 2.0 Array)   1442542_at (Mouse Genome 430 2.0 Array)   1456647_a_at (Mouse Genome 430 2.0 Array)   1456665_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073970
Ensembl peptide - ENSMUSP00000151287
Ensembl peptide - ENSMUSP00000151483
Ensembl peptide - ENSMUSP00000151968
Ensembl peptide - ENSMUSP00000090335
NCBI entrez gene - 14051     See in Manteia.
MGI - MGI:1337104
RefSeq - XM_017313799
RefSeq - XM_006512528
RefSeq - XM_006512529
RefSeq - XM_006512530
RefSeq - XM_011243112
RefSeq - XM_011243115
RefSeq - XM_017313798
RefSeq - NM_001347372
RefSeq - NM_010167
RefSeq - XM_006512522
RefSeq - XM_006512523
RefSeq - XM_006512524
RefSeq - XM_006512526
RefSeq - XM_006512527
RefSeq Peptide - NP_001334301
RefSeq Peptide - NP_034297
swissprot - A0A1W2P897
swissprot - Q9Z191
swissprot - A0A1W2P721
swissprot - Q8BY78
Ensembl - ENSMUSG00000010461
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eya4ENSDARG00000012397Danio rerio
 EYA4ENSGALG00000031656Gallus gallus
 EYA4ENSG00000112319Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eya1 / P97767 / Eyes absent homolog 1 / Q99502* / EYA transcriptional coactivator and phosphatase 1*ENSMUSG0000002593270
Eya2 / O08575 / Eyes absent homolog 2 / O00167* / EYA transcriptional coactivator and phosphatase 2*ENSMUSG0000001789750
Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*ENSMUSG0000002888637


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028472  Eyes absent family
 IPR028478  Eyes absent homologue 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0016576 histone dephosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IBA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0003330 abnormal auditory tube "anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0006018 abnormal tympanic membrane morphology "any structural alterations in the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane consitutes the boundary between the external and middle ear." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:46639:]
Show

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009891 abnormal palate bone morphology "any structural anomaly of the maxillary or palatine shelves that comprise the bones of the hard palate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Eya4tm1Jse/Eya4tm1Jse
Genetic Background: 129S6/SvEvTac-Eya4tm1Jse

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tgm3we/Tgm3we-Bkr
Genetic Background: involves: 129 * C57BL/10 * UW

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0030154 abnormal tympanic cavity morphology "any structural anomaly of the small, air-filled, mucosa-lined cavity that is located in the petrous portion of the temporal bone and houses the auditory ossicles and intratympanic muscles (tensor tympani and stapedius) as well as the chorda tympani and the tympanic plexus of nerves; it is split into two parts: the tympanic cavity proper (the space directly internal to the tympanic membrane) and the epitympanic recess or attic (the space superior to the tympanic membrane)" []
Show

Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0030226 middle ear polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the middle ear" [MGI:anna]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0030410 middle ear effusion "fluid accumulation in the middle ear cavity due to dysfunction of the Eustachian tube" [https://www.medscape.org/viewarticle/730698, PMID:1267372]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0030413 tympanic membrane retraction "a condition in which a segment of the tympanic membrane (eardrum) collapses inwards towards the middle ear space and lies more medially (deeper) than its normal position; the retracted segment is often known as a retraction pocket" [http://allearseducation.org/resources/Tutorial-10-Retractions.pdf, https://en.wikipedia.org/wiki/Tympanic_membrane_retraction]
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Allelic Composition: Ldhab/Ldhab
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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