ENSDARG00000012397


Danio rerio

Features
Gene ID: ENSDARG00000012397
  
Biological name :eya4
  
Synonyms : eya4 / EYA transcriptional coactivator and phosphatase 4
  
Possible biological names infered from orthology : Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA. / O95677 / Q9Z191
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 31439713
Gene end: 31512497
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000113606
Ensembl peptide - ENSDARP00000130998
Ensembl peptide - ENSDARP00000122519
Ensembl peptide - ENSDARP00000115424
Ensembl peptide - ENSDARP00000113103
NCBI entrez gene - 541552     See in Manteia.
RefSeq - NM_001282173
RefSeq - XM_005162316
RefSeq - XM_021469796
RefSeq - XM_021469797
RefSeq - XM_021469798
RefSeq - XM_021469799
RefSeq - XM_021469800
RefSeq - XM_021469801
RefSeq - XM_005162314
RefSeq Peptide - NP_001269102
swissprot - E9QGZ3
swissprot - E9QGF5
swissprot - E9QIR1
swissprot - A0A0R4IA41
swissprot - F1Q5R9
ZFIN ID - ZDB-GENE-050327-93
Ensembl - ENSDARG00000012397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EYA4ENSGALG00000031656Gallus gallus
 EYA4ENSG00000112319Homo sapiens
 Eya4ENSMUSG00000010461Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eya1 / EYA transcriptional coactivator and phosphatase 1 / P97767* / Q99502* / Eyes absent homolog 1 *ENSDARG0000001425963
eya2 / EYA transcriptional coactivator and phosphatase 2 / O00167* / O08575* / Eyes absent homolog 2 *ENSDARG0000001898442
eya3 / EYA transcriptional coactivator and phosphatase 3 / P97480* / Q99504* / Eyes absent homolog 3 *ENSDARG0000003610035


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028472  Eyes absent family
 IPR028478  Eyes absent homologue 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001964 startle response IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0016576 histone dephosphorylation IBA
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0048923 posterior lateral line neuromast hair cell differentiation IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000051 otic vesicle otic vesicle shape , abnormal
otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal malformed , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula decreased amount , abnormal
hair cell anterior macula stereocilium malformed , abnormal
hair cell anterior macula stereocilium decreased amount , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
posterior lateral line neuromast neuromast hair cell decreased amount , abnormal
Show

 ZFA:0007054 pillar of the anterior semicircular canal pillar of the anterior semicircular canal malformed , abnormal
Show

 ZFA:0007055 pillar of the lateral semicircular canal pillar of the lateral semicircular canal malformed , abnormal
Show

 ZFA:0007056 pillar of the posterior semicircular canal pillar of the posterior semicircular canal malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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