ENSDARG00000014259


Danio rerio

Features
Gene ID: ENSDARG00000014259
  
Biological name :eya1
  
Synonyms : eya1 / EYA transcriptional coactivator and phosphatase 1
  
Possible biological names infered from orthology : Eyes absent homolog 1 / P97767 / Q99502
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 13869092
Gene end: 14015459
  
Corresponding Affymetrix probe sets: Dr.20911.1.S1_at (Zebrafish Array)   NM_131193_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000117417
Ensembl peptide - ENSDARP00000144570
Ensembl peptide - ENSDARP00000120804
Ensembl peptide - ENSDARP00000025942
Ensembl peptide - ENSDARP00000076036
Ensembl peptide - ENSDARP00000113569
NCBI entrez gene - 30436     See in Manteia.
RefSeq - NM_131193
RefSeq Peptide - NP_571268
swissprot - E9QII4
swissprot - F1QNU4
swissprot - E9QJ32
swissprot - Q6DBY3
ZFIN ID - ZDB-GENE-990712-18
Ensembl - ENSDARG00000014259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EYA1ENSGALG00000043033Gallus gallus
 EYA1ENSG00000104313Homo sapiens
 Eya1ENSMUSG00000025932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eya4 / EYA transcriptional coactivator and phosphatase 4 / O95677* / Q9Z191* / Mus musculus EYA transcriptional coactivator and phosphatase 4 (Eya4), transcript variant 2, mRNA.*ENSDARG0000001239767
eya2 / EYA transcriptional coactivator and phosphatase 2 / O00167* / O08575* / Eyes absent homolog 2 *ENSDARG0000001898449
eya3 / EYA transcriptional coactivator and phosphatase 3 / P97480* / Q99504* / Eyes absent homolog 3 *ENSDARG0000003610037


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028471  Eyes absent homologue 1
 IPR028472  Eyes absent family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0016576 histone dephosphorylation IBA
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042471 ear morphogenesis IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0071600 otic vesicle morphogenesis IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle malformed , abnormal
otic vesicle apoptotic , abnormal
otic vesicle decreased size , abnormal
otic vesicle decreased width , abnormal
otic vesicle oblong , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton decreased size , abnormal
Show

 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
Show

 ZFA:0000118 hypophysis hypophysis quality , abnormal
Show

 ZFA:0000123 liver liver hypoplastic , abnormal
liver quality , abnormal
Show

 ZFA:0000166 lateral crista lateral crista absent , abnormal
Show

 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear morphology , abnormal
Show

 ZFA:0000225 lateral crista primordium lateral crista primordium aplastic , abnormal
Show

 ZFA:0000236 mandibular muscle mandibular muscle hypoplastic , abnormal
Show

 ZFA:0000247 cranial nerve VIII cranial nerve VIII increased length , abnormal
cranial nerve VIII decreased thickness , abnormal
Show

 ZFA:0000281 hair cell posterior macula hair cell posterior macula decreased amount , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000386 macula macula shape , abnormal
Show

 ZFA:0000411 posterior crista primordium posterior crista primordium aplastic , abnormal
Show

 ZFA:0000431 semicircular canal semicircular canal disorganized , abnormal
semicircular canal shape , abnormal
Show

 ZFA:0000468 anterior crista primordium anterior crista primordium aplastic , abnormal
Show

 ZFA:0000566 posterior crista posterior crista absent , abnormal
Show

 ZFA:0000619 anterior crista anterior crista absent , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula decreased amount , abnormal
Show

 ZFA:0000814 opercular lateral line neuromast opercular lateral line neuromast absent , abnormal
Show

 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
posterior lateral line neuromast posterior-most region absent , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism circling , abnormal
whole organism movement behavioral quality , abnormal
Show

 ZFA:0001114 head head circular , abnormal
Show

 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium apoptotic , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton shape , abnormal
mandibular arch skeleton circular , abnormal
mandibular arch skeleton morphology , abnormal
Show

 ZFA:0001271 neurohypophysis neurohypophysis quality , abnormal
Show

 ZFA:0001282 adenohypophysis adenohypophysis poorly differentiated , abnormal
adenohypophysis decreased size , abnormal
adenohypophysis disorganized , abnormal
adenohypophysis secretory granule mislocalised , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001469 lateral line lateral line morphology , abnormal
Show

 ZFA:0001617 otolith otolith decreased size , abnormal
otolith quality , abnormal
Show

 ZFA:0009100 peptide hormone secreting cell peptide hormone secreting cell structure , abnormal
Show

 ZFA:0009155 somatotropin secreting cell somatotropin secreting cell absent , abnormal
Show

 ZFA:0009204 prolactin secreting cell prolactin secreting cell mislocalised , abnormal
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 ZFA:0009205 melanocyte stimulating hormone secreting cell melanocyte stimulating hormone secreting cell absent , abnormal
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 ZFA:0009216 adrenocorticotropic hormone secreting cell adrenocorticotropic hormone secreting cell absent , abnormal
Show

 ZFA:0009218 thyroid stimulating hormone secreting cell thyroid stimulating hormone secreting cell absent , abnormal
Show

 ZFA:0009366 hair cell hair cell apoptotic , abnormal
hair cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction






 

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