ENSG00000183955


Homo sapiens

Features
Gene ID: ENSG00000183955
  
Biological name :KMT5A
  
Synonyms : KMT5A / lysine methyltransferase 5A / Q9NQR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 123383773
Gene end: 123409358
  
Corresponding Affymetrix probe sets: 220200_s_at (Human Genome U133 Plus 2.0 Array)   225094_at (Human Genome U133 Plus 2.0 Array)   225118_at (Human Genome U133 Plus 2.0 Array)   228443_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332995
Ensembl peptide - ENSP00000413811
Ensembl peptide - ENSP00000406830
Ensembl peptide - ENSP00000384629
NCBI entrez gene - 387893     See in Manteia.
OMIM - 607240
RefSeq - XM_011538333
RefSeq - NM_020382
RefSeq - XM_006719394
RefSeq Peptide - NP_065115
swissprot - C9JKQ0
swissprot - Q9NQR1
swissprot - A0A0C4DFR3
swissprot - F8WC45
Ensembl - ENSG00000183955
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt5aaENSDARG00000105231Danio rerio
 kmt5abENSDARG00000104114Danio rerio
 KMT5AENSGALG00000003325Gallus gallus
 Kmt5aENSMUSG00000049327Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR016858  Class V SAM-dependent methyltransferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0018026 peptidyl-lysine monomethylation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034770 histone H4-K20 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016278 lysine N-methyltransferase activity TAS
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042799 histone methyltransferase activity (H4-K20 specific) TAS


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172943 PHF8 / Q9UPP1 / PHD finger protein 8  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction






 

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