ENSMUSG00000049327


Mus musculus

Features
Gene ID: ENSMUSG00000049327
  
Biological name :Kmt5a
  
Synonyms : Kmt5a / lysine methyltransferase 5A
  
Possible biological names infered from orthology : Q9NQR1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 124439930
Gene end: 124462308
  
Corresponding Affymetrix probe sets: 10525733 (MoGene1.0st)   1426406_at (Mouse Genome 430 2.0 Array)   1441557_at (Mouse Genome 430 2.0 Array)   1459779_s_at (Mouse Genome 430 2.0 Array)   1460687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052953
Ensembl peptide - ENSMUSP00000143765
Ensembl peptide - ENSMUSP00000143207
Ensembl peptide - ENSMUSP00000098275
NCBI entrez gene - 67956     See in Manteia.
MGI - MGI:1915206
RefSeq - XM_006530450
RefSeq - NM_001310723
RefSeq - NM_001310725
RefSeq - NM_001310727
RefSeq - NM_030241
RefSeq Peptide - NP_001297656
RefSeq Peptide - NP_084517
RefSeq Peptide - NP_001297652
RefSeq Peptide - NP_001297654
swissprot - D3YXI6
swissprot - A0A0G2JGZ8
swissprot - E9QNB8
swissprot - A0A0G2JFK5
Ensembl - ENSMUSG00000049327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt5aaENSDARG00000105231Danio rerio
 kmt5abENSDARG00000104114Danio rerio
 KMT5AENSGALG00000003325Gallus gallus
 KMT5AENSG00000183955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR016858  Class V SAM-dependent methyltransferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0018026 peptidyl-lysine monomethylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016279 protein-lysine N-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Condensation of Prophase Chromosomes
PKMTs methylate histone lysines
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nat1Rgsc1523/Nat1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: KitW-v/Kit+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000041229 Phf8 / Q80TJ7 / Histone lysine demethylase PHF8 / Q9UPP1* / PHD finger protein 8*  / reaction
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction






 

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