ENSG00000070495


Homo sapiens

Features
Gene ID: ENSG00000070495
  
Biological name :JMJD6
  
Synonyms : arginine demethylase and lysine hydroxylase / JMJD6 / Q6NYC1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.1
Gene start: 76712832
Gene end: 76726799
  
Corresponding Affymetrix probe sets: 1552629_a_at (Human Genome U133 Plus 2.0 Array)   212722_s_at (Human Genome U133 Plus 2.0 Array)   212723_at (Human Genome U133 Plus 2.0 Array)   215233_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394085
Ensembl peptide - ENSP00000483941
Ensembl peptide - ENSP00000465330
Ensembl peptide - ENSP00000442362
Ensembl peptide - ENSP00000302916
Ensembl peptide - ENSP00000380750
NCBI entrez gene - 23210     See in Manteia.
OMIM - 604914
RefSeq - NM_015167
RefSeq - NM_001081461
RefSeq Peptide - NP_001074930
RefSeq Peptide - NP_055982
swissprot - Q6NYC1
swissprot - B2WTI3
swissprot - K7EJU9
swissprot - B2WTI4
Ensembl - ENSG00000070495
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jmjd6ENSDARG00000102896Danio rerio
 JMJD6ENSGALG00000001802Gallus gallus
 Jmjd6ENSMUSG00000056962Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JMJD4 / Q9H9V9 / jumonji domain containing 4ENSG0000008169221


Protein motifs (from Interpro)
Interpro ID Name
 IPR003347  JmjC domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0018395 peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043654 recognition of apoptotic cell IEA
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0070078 histone H3-R2 demethylation IDA
 biological_processGO:0070079 histone H4-R3 demethylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0033746 histone demethylase activity (H3-R2 specific) IDA
 molecular_functionGO:0033749 histone demethylase activity (H4-R3 specific) IDA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0070815 peptidyl-lysine 5-dioxygenase activity IDA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction






 

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