ENSG00000132703


Homo sapiens

Features
Gene ID: ENSG00000132703
  
Biological name :APCS
  
Synonyms : amyloid P component, serum / APCS / P02743
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.2
Gene start: 159587825
Gene end: 159588865
  
Corresponding Affymetrix probe sets: 206350_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000255040
NCBI entrez gene - 325     See in Manteia.
OMIM - 104770
RefSeq - NM_001639
RefSeq Peptide - NP_001630
swissprot - P02743
swissprot - V9HWP0
Ensembl - ENSG00000132703
  
Related genetic diseases (OMIM): 104770 - {?Amyloidosis, secondary, susceptibility to}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-270n8.1ENSDARG00000045089Danio rerio
 ENSGALG00000039887Gallus gallus
 CRPENSGALG00000022137Gallus gallus
 ApcsENSMUSG00000026542Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRP / P02741 / C-reactive proteinENSG0000013269351
NPTX1 / Q15818 / neuronal pentraxin 1ENSG0000017124626
PTX4 / Q96A99 / pentraxin 4ENSG0000025169226
NPTXR / O95502 / neuronal pentraxin receptorENSG0000022189026
NPTX2 / P47972 / neuronal pentraxin 2ENSG0000010623626
PTX3 / P26022 / pentraxin 3ENSG0000016366125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001759  Pentraxin-related
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030476  Pentaxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002674 negative regulation of acute inflammatory response IC
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006953 acute-phase response TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IDA
 biological_processGO:0044871 negative regulation by host of viral glycoprotein metabolic process IDA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0045656 negative regulation of monocyte differentiation IDA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:0048525 negative regulation of viral process IDA
 biological_processGO:0051131 chaperone-mediated protein complex assembly TAS
 biological_processGO:0061045 negative regulation of wound healing IC
 biological_processGO:1903016 negative regulation of exo-alpha-sialidase activity IDA
 biological_processGO:1903019 negative regulation of glycoprotein metabolic process IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0001849 complement component C1q binding IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046790 virion binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding TAS


Pathways (from Reactome)
Pathway description
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000132703 APCS / P02743 / amyloid P component, serum  / complex / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / complex / reaction






 

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