ENSG00000163661


Homo sapiens

Features
Gene ID: ENSG00000163661
  
Biological name :PTX3
  
Synonyms : P26022 / pentraxin 3 / PTX3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.32
Gene start: 157436789
Gene end: 157443628
  
Corresponding Affymetrix probe sets: 206157_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295927
NCBI entrez gene - 5806     See in Manteia.
OMIM - 602492
RefSeq - NM_002852
RefSeq Peptide - NP_002843
swissprot - P26022
Ensembl - ENSG00000163661
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptx3aENSDARG00000068275Danio rerio
 ptx3bENSDARG00000079515Danio rerio
 PTX3ENSGALG00000028284Gallus gallus
 Ptx3ENSMUSG00000027832Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPTX2 / P47972 / neuronal pentraxin 2ENSG0000010623623
NPTX1 / Q15818 / neuronal pentraxin 1ENSG0000017124620
NPTXR / O95502 / neuronal pentraxin receptorENSG0000022189020
PTX4 / Q96A99 / pentraxin 4ENSG0000025169220
CRP / P02741 / C-reactive proteinENSG0000013269315
APCS / P02743 / amyloid P component, serumENSG0000013270314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001759  Pentraxin-related
 IPR006558  LamG-like jellyroll fold
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030476  Pentaxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0008228 opsonization IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IDA
 biological_processGO:0044871 negative regulation by host of viral glycoprotein metabolic process IDA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:1903016 negative regulation of exo-alpha-sialidase activity IDA
 biological_processGO:1903019 negative regulation of glycoprotein metabolic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0001849 complement component C1q binding IDA
 molecular_functionGO:0001872 (1->3)-beta-D-glucan binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046790 virion binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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