ENSG00000132693


Homo sapiens

Features
Gene ID: ENSG00000132693
  
Biological name :CRP
  
Synonyms : C-reactive protein / CRP / P02741
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.2
Gene start: 159712289
Gene end: 159714589
  
Corresponding Affymetrix probe sets: 205753_at (Human Genome U133 Plus 2.0 Array)   37020_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357093
Ensembl peptide - ENSP00000402788
Ensembl peptide - ENSP00000255030
Ensembl peptide - ENSP00000357091
Ensembl peptide - ENSP00000357092
NCBI entrez gene - 1401     See in Manteia.
OMIM - 123260
RefSeq - NM_000567
RefSeq - XM_011509207
RefSeq Peptide - NP_001315986
RefSeq Peptide - NP_000558
swissprot - P02741
swissprot - Q5VVP7
swissprot - C9JRE9
Ensembl - ENSG00000132693
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-270n8.1ENSDARG00000045089Danio rerio
 ENSGALG00000039887Gallus gallus
 CRPENSGALG00000022137Gallus gallus
 CrpENSMUSG00000037942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APCS / P02743 / amyloid P component, serumENSG0000013270351
PTX3 / P26022 / pentraxin 3ENSG0000016366126
PTX4 / Q96A99 / pentraxin 4ENSG0000025169225
NPTXR / O95502 / neuronal pentraxin receptorENSG0000022189025
NPTX2 / P47972 / neuronal pentraxin 2ENSG0000010623625
NPTX1 / Q15818 / neuronal pentraxin 1ENSG0000017124624


Protein motifs (from Interpro)
Interpro ID Name
 IPR001759  Pentraxin-related
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030476  Pentaxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006953 acute-phase response TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0008228 opsonization TAS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IDA
 biological_processGO:0010888 negative regulation of lipid storage IDA
 biological_processGO:0032930 positive regulation of superoxide anion generation IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium TAS
 biological_processGO:0097756 negative regulation of blood vessel diameter IMP
 biological_processGO:2000482 regulation of interleukin-8 secretion IDA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001849 complement component C1q binding IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0033265 choline binding TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IPI


Pathways (from Reactome)
Pathway description
Classical antibody-mediated complement activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132693 CRP / P02741 / C-reactive protein  / complex
 ENSG00000173369 C1QB / P02746 / complement C1q B chain  / complex
 ENSG00000159189 C1QC / P02747 / complement C1q C chain  / complex
 ENSG00000173372 C1QA / P02745 / complement C1q A chain  / complex






 

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