ENSMUSG00000037942


Mus musculus

Features
Gene ID: ENSMUSG00000037942
  
Biological name :Crp
  
Synonyms : C-reactive protein / Crp / P14847
  
Possible biological names infered from orthology : P02741
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 172698055
Gene end: 172833031
  
Corresponding Affymetrix probe sets: 10351852 (MoGene1.0st)   1421946_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044665
NCBI entrez gene - 12944     See in Manteia.
MGI - MGI:88512
RefSeq - NM_007768
RefSeq Peptide - NP_031794
swissprot - P14847
Ensembl - ENSMUSG00000037942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-270n8.1ENSDARG00000045089Danio rerio
 ENSGALG00000039887Gallus gallus
 CRPENSGALG00000022137Gallus gallus
 CRPENSG00000132693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mptx1ENSMUSG0000002653148
Apcs / P12246 / serum amyloid P-component / P02743* / amyloid P component, serum*ENSMUSG0000002654245
Mptx2 / mucosal pentraxin 2ENSMUSG0000007918044
Ptx4 / pentraxin-4 isoform 2 / Q96A99* / pentraxin 4*ENSMUSG0000004417224
Ptx3 / P48759 / Pentraxin-related protein PTX3 / P26022* / pentraxin 3*ENSMUSG0000002783224
Nptxr / neuronal pentraxin receptor / O95502*ENSMUSG0000002242123
Nptx2 / O70340 / Neuronal pentraxin-2 / P47972*ENSMUSG0000005999123
Npcd / NPTXR* / O95502* / neuronal pentraxin receptor*ENSMUSG0000008983723
Nptx1 / Q62443 / neuronal pentraxin 1 / Q15818*ENSMUSG0000002558222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001759  Pentraxin-related
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030476  Pentaxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010745 negative regulation of macrophage derived foam cell differentiation IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0097756 negative regulation of blood vessel diameter IEA
 biological_processGO:2000482 regulation of interleukin-8 secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0001849 complement component C1q binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA


Pathways (from Reactome)
Pathway description
Classical antibody-mediated complement activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Crptm1Hjf/Crp+
Genetic Background: C57BL/6-Crptm1Hjf

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

 MP:0005146 decreased circulating VLDL cholesterol level "less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crptm1Hjf/Crptm1Hjf,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Crptm1Hjf Ldlrtm1Her

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Crptm1Hjf/Crptm1Hjf
Genetic Background: B6.Cg-Crptm1Hjf Apoetm1Unc

 MP:0010212 abnormal circulating C-reactive protein level "deviation from the normal levels of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D12.776.034.145, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csgalnact1tm1.1Nari/Csgalnact1tm1.1Nari
Genetic Background: involves: C57BL/6J

Allelic Composition: Crptm1Hjf/Crp+
Genetic Background: C57BL/6-Crptm1Hjf

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037942 Crp / P14847 / C-reactive protein / P02741*  / complex
 ENSMUSG00000036887 C1qa / P98086 / Complement C1q subcomponent subunit A / P02745* / complement C1q A chain*  / complex
 ENSMUSG00000036905 C1qb / P14106 / Complement C1q subcomponent subunit B / P02746* / complement C1q B chain*  / complex
 ENSMUSG00000036896 C1qc / Q02105 / Complement C1q subcomponent subunit C / P02747* / complement C1q C chain*  / complex






 

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