ENSMUSG00000027832


Mus musculus

Features
Gene ID: ENSMUSG00000027832
  
Biological name :Ptx3
  
Synonyms : P48759 / Pentraxin-related protein PTX3 / Ptx3
  
Possible biological names infered from orthology : P26022 / pentraxin 3
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 66219910
Gene end: 66225805
  
Corresponding Affymetrix probe sets: 10492448 (MoGene1.0st)   1418666_at (Mouse Genome 430 2.0 Array)   1456903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029421
NCBI entrez gene - 19288     See in Manteia.
MGI - MGI:104641
RefSeq - NM_008987
RefSeq Peptide - NP_033013
swissprot - P48759
Ensembl - ENSMUSG00000027832
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptx3aENSDARG00000068275Danio rerio
 ptx3bENSDARG00000079515Danio rerio
 PTX3ENSGALG00000028284Gallus gallus
 PTX3ENSG00000163661Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nptx2 / O70340 / Neuronal pentraxin-2 / P47972*ENSMUSG0000005999122
Ptx4 / pentraxin-4 isoform 2 / Q96A99* / pentraxin 4*ENSMUSG0000004417220
Nptxr / neuronal pentraxin receptor / O95502*ENSMUSG0000002242120
Nptx1 / Q62443 / neuronal pentraxin 1 / Q15818*ENSMUSG0000002558220
Npcd / NPTXR* / O95502* / neuronal pentraxin receptor*ENSMUSG0000008983718
Crp / P14847 / C-reactive protein / P02741*ENSMUSG0000003794214
Apcs / P12246 / serum amyloid P-component / P02743* / amyloid P component, serum*ENSMUSG0000002654214
Mptx1ENSMUSG0000002653113
Mptx2 / mucosal pentraxin 2ENSMUSG0000007918013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001759  Pentraxin-related
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030476  Pentaxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IMP
 biological_processGO:0008228 opsonization IMP
 biological_processGO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IEA
 biological_processGO:0044871 negative regulation by host of viral glycoprotein metabolic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0046597 negative regulation of viral entry into host cell IEA
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:1903016 negative regulation of exo-alpha-sialidase activity IEA
 biological_processGO:1903019 negative regulation of glycoprotein metabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0001849 complement component C1q binding IEA
 molecular_functionGO:0001872 (1->3)-beta-D-glucan binding IMP
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046790 virion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxb1tm2Mrc/Hoxb1tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129 * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Gsdma3M1Btlr/Gsdma3M1Btlr
Genetic Background: either: C57BL/6J-Gsdma3M1Btlr or (involves: C3H * C57BL/6J)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129 * C57BL/6J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxb1tm2Mrc/Hoxb1tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxb1tm2Mrc/Hoxb1tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009372 abnormal cumulus oophorus "atypical formation of or inability to produce a mass of epithelial granulosa cells around the oocyte in the maturing Graafian follicle; the cumulus oophorus begins to expand dramatically when cumulus cells are induced to synthesize hyaluronic acid which aggregates in a viscous intercellular matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Ptx3tm1Mant/Ptx3tm1Mant
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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