ENSMUSG00000026542


Mus musculus

Features
Gene ID: ENSMUSG00000026542
  
Biological name :Apcs
  
Synonyms : Apcs / P12246 / serum amyloid P-component
  
Possible biological names infered from orthology : amyloid P component, serum / P02743
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 172893961
Gene end: 172895041
  
Corresponding Affymetrix probe sets: 10360328 (MoGene1.0st)   1419059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027824
NCBI entrez gene - 20219     See in Manteia.
MGI - MGI:98229
RefSeq - NM_011318
RefSeq Peptide - NP_035448
swissprot - P12246
swissprot - Q4JFI8
Ensembl - ENSMUSG00000026542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-270n8.1ENSDARG00000045089Danio rerio
 ENSGALG00000039887Gallus gallus
 CRPENSGALG00000022137Gallus gallus
 APCSENSG00000132703Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mptx2 / mucosal pentraxin 2ENSMUSG0000007918046
Crp / P14847 / C-reactive protein / P02741*ENSMUSG0000003794246
Mptx1ENSMUSG0000002653146
Nptx1 / Q62443 / neuronal pentraxin 1 / Q15818*ENSMUSG0000002558227
Nptx2 / O70340 / Neuronal pentraxin-2 / P47972*ENSMUSG0000005999127
Nptxr / neuronal pentraxin receptor / O95502*ENSMUSG0000002242125
Ptx4 / pentraxin-4 isoform 2 / Q96A99* / pentraxin 4*ENSMUSG0000004417225
Npcd / NPTXR* / O95502* / neuronal pentraxin receptor*ENSMUSG0000008983724
Ptx3 / P48759 / Pentraxin-related protein PTX3 / P26022* / pentraxin 3*ENSMUSG0000002783223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001759  Pentraxin-related
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030476  Pentaxin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0044869 negative regulation by host of viral exo-alpha-sialidase activity IEA
 biological_processGO:0044871 negative regulation by host of viral glycoprotein metabolic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IEA
 biological_processGO:0048525 negative regulation of viral process IEA
 biological_processGO:1903016 negative regulation of exo-alpha-sialidase activity IEA
 biological_processGO:1903019 negative regulation of glycoprotein metabolic process IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0001849 complement component C1q binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046790 virion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hps5ru2-r/Hps5ru2-r
Genetic Background: C57BL/10

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcstm1Mpe
Genetic Background: 129.Cg-Apcstm1Mpe

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

Allelic Composition: Apcstm1Smae/Apcstm1Smae
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apcstm1Smae/Apcstm1Smae
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcstm1Mpe
Genetic Background: 129.Cg-Apcstm1Mpe

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcstm1Mpe
Genetic Background: 129.Cg-Apcstm1Mpe

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Sh2d1atm2Vei/Sh2d1atm2Vei,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Apcstm1Mpe/Apcs+
Genetic Background: B6.Cg-Apcstm1Mpe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr