ENSG00000087206


Homo sapiens

Features
Gene ID: ENSG00000087206
  
Biological name :UIMC1
  
Synonyms : Q96RL1 / ubiquitin interaction motif containing 1 / UIMC1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.2
Gene start: 176905005
Gene end: 177022633
  
Corresponding Affymetrix probe sets: 220746_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423534
Ensembl peptide - ENSP00000421926
Ensembl peptide - ENSP00000423717
Ensembl peptide - ENSP00000427480
Ensembl peptide - ENSP00000425566
Ensembl peptide - ENSP00000425163
Ensembl peptide - ENSP00000423885
Ensembl peptide - ENSP00000366434
NCBI entrez gene - 51720     See in Manteia.
OMIM - 609433
RefSeq - XM_017009579
RefSeq - XM_005265936
RefSeq - XM_006714871
RefSeq - XM_006714874
RefSeq - XM_011534568
RefSeq - XM_011534570
RefSeq - XM_017009574
RefSeq - XM_017009575
RefSeq - XM_017009576
RefSeq - XM_017009577
RefSeq - XM_017009578
RefSeq - NM_001199297
RefSeq - NM_001199298
RefSeq - NM_001317961
RefSeq - NM_016290
RefSeq - XM_005265930
RefSeq - XM_005265932
RefSeq - XM_005265933
RefSeq - XM_005265934
RefSeq - XM_005265935
RefSeq Peptide - NP_001186227
RefSeq Peptide - NP_001304890
RefSeq Peptide - NP_057374
RefSeq Peptide - NP_001186226
swissprot - A0A024R7R0
swissprot - D6RDZ5
swissprot - Q96RL1
swissprot - D6RCQ3
swissprot - D6RC40
swissprot - D6R9M3
Ensembl - ENSG00000087206
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX649250.1ENSDARG00000091187Danio rerio
 UIMC1ENSGALG00000001158Gallus gallus
 Uimc1ENSMUSG00000025878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003903  Ubiquitin interacting motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0045739 positive regulation of DNA repair IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0070537 histone H2A K63-linked deubiquitination IMP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0070531 BRCA1-A complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163322 Q6UWZ7 / ABRAXAS1 / abraxas 1, BRCA1 A complex subunit  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / complex / reaction
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / complex / reaction
 ENSG00000067369 Q12888 / TP53BP1 / tumor protein p53 binding protein 1  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / complex / reaction






 

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