ENSG00000110066


Homo sapiens

Features
Gene ID: ENSG00000110066
  
Biological name :KMT5B
  
Synonyms : KMT5B / lysine methyltransferase 5B / Q4FZB7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.2
Gene start: 68154863
Gene end: 68213828
  
Corresponding Affymetrix probe sets: 218242_s_at (Human Genome U133 Plus 2.0 Array)   222566_at (Human Genome U133 Plus 2.0 Array)   222759_at (Human Genome U133 Plus 2.0 Array)   242646_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385965
Ensembl peptide - ENSP00000385640
Ensembl peptide - ENSP00000387685
Ensembl peptide - ENSP00000484858
Ensembl peptide - ENSP00000411146
Ensembl peptide - ENSP00000406377
Ensembl peptide - ENSP00000403233
Ensembl peptide - ENSP00000402921
Ensembl peptide - ENSP00000305899
Ensembl peptide - ENSP00000313027
Ensembl peptide - ENSP00000384724
Ensembl peptide - ENSP00000385005
NCBI entrez gene - 51111     See in Manteia.
OMIM - 610881
RefSeq - XM_017017880
RefSeq - NM_001300909
RefSeq - NM_016028
RefSeq - NM_017635
RefSeq - XM_005274035
RefSeq - XM_005274036
RefSeq - XM_006718581
RefSeq - XM_011545091
RefSeq - XM_011545092
RefSeq - XM_011545093
RefSeq - XM_011545094
RefSeq - XM_017017876
RefSeq - XM_017017877
RefSeq - XM_017017878
RefSeq - XM_017017879
RefSeq - NM_001300907
RefSeq - NM_001300908
RefSeq Peptide - NP_001287837
RefSeq Peptide - NP_001287838
RefSeq Peptide - NP_057112
RefSeq Peptide - NP_060105
RefSeq Peptide - NP_001287836
swissprot - F8WFA4
swissprot - H7BXP2
swissprot - Q4FZB7
swissprot - A0A0A0MT19
swissprot - C9JP58
swissprot - C9JFG1
swissprot - C9J6S5
swissprot - B7WNX0
swissprot - B5MCB3
Ensembl - ENSG00000110066
  
Related genetic diseases (OMIM): 617788 - Mental retardation, autosomal dominant 51, 617788
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt5bENSDARG00000041081Danio rerio
 KMT5BENSGALG00000014152Gallus gallus
 Kmt5bENSMUSG00000045098Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KMT5C / Q86Y97 / lysine methyltransferase 5CENSG0000013324723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR025790  Histone-lysine N-methyltransferase, Suvar4-20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034773 histone H4-K20 trimethylation IEA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0042799 histone methyltransferase activity (H4-K20 specific) IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction






 

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