MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi
Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Traddtm1.1Zgl/Traddtm1.1Zgl Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0001973 | increased thermal nociceptive threshold | "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194] |
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi
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MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Traddtm1.1Zgl/Traddtm1.1Zgl Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0002401 | abnormal lymphopoiesis | "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0002942 | decreased circulating alanine transaminase level | "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi
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MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0004647 | decreased lumbar vertebrae number | "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi
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MP:0004816 | abnormal class switch recombination | "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0008008 | early cellular replicative senescence | "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0008058 | abnormal DNA repair | "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0008409 | increased cellular sensitivity to hydroxyurea | "greater incidence of cell death following exposure to hydroxyurea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0008410 | increased cellular sensitivity to ultraviolet irradiation | "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi
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MP:0010101 | increased sacral vertebrae number | "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Spns2tm1a(KOMP)Wtsi/Spns2tm1a(KOMP)Wtsi Genetic Background: B6JTyr;B6N-Spns2tm1a(KOMP)Wtsi/Wtsi
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Traddtm1.1Zgl/Traddtm1.1Zgl Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Traddtm1.1Zgl/Traddtm1.1Zgl Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw Genetic Background: involves: 129 * C57BL/6J
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