ENSMUSG00000059851


Mus musculus

Features
Gene ID: ENSMUSG00000059851
  
Biological name :Kmt5c
  
Synonyms : Kmt5c / Mus musculus lysine methyltransferase 5C (Kmt5c), transcript variant 3, mRNA. / Q6Q783
  
Possible biological names infered from orthology : lysine methyltransferase 5C / Q86Y97
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 4740115
Gene end: 4747514
  
Corresponding Affymetrix probe sets: 10549700 (MoGene1.0st)   1424059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119323
Ensembl peptide - ENSMUSP00000114445
Ensembl peptide - ENSMUSP00000124663
Ensembl peptide - ENSMUSP00000096452
Ensembl peptide - ENSMUSP00000104223
Ensembl peptide - ENSMUSP00000104224
NCBI entrez gene - 232811     See in Manteia.
MGI - MGI:2385262
RefSeq - XM_006539774
RefSeq - NM_001115018
RefSeq - NM_001358044
RefSeq - NM_146177
RefSeq - XM_006539769
RefSeq - XM_006539770
RefSeq - XM_006539771
RefSeq - XM_006539772
RefSeq Peptide - NP_666289
RefSeq Peptide - NP_001108490
RefSeq Peptide - NP_001344973
swissprot - D3Z2F5
swissprot - Q6Q783
swissprot - E0CXW4
swissprot - F6XZN9
Ensembl - ENSMUSG00000059851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt5cENSDARG00000075461Danio rerio
 KMT5CENSG00000133247Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kmt5b / Q3U8K7 / Histone-lysine N-methyltransferase KMT5B / Q4FZB7* / lysine methyltransferase 5B*ENSMUSG0000004509844


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR025790  Histone-lysine N-methyltransferase, Suvar4-20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034773 histone H4-K20 trimethylation IDA
 cellular_componentGO:0000780 condensed nuclear chromosome, centromeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005720 nuclear heterochromatin ISO
 cellular_componentGO:0005721 pericentric heterochromatin ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity IEA
 molecular_functionGO:0042799 histone methyltransferase activity (H4-K20 specific) IDA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0008409 increased cellular sensitivity to hydroxyurea "greater incidence of cell death following exposure to hydroxyurea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Kmt5btm1.1Jnw/Kmt5btm1.1Jnw,Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction






 

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