ENSG00000276600


Homo sapiens

Features
Gene ID: ENSG00000276600
  
Biological name :RAB7B
  
Synonyms : Q96AH8 / RAB7B / RAB7B, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 205976740
Gene end: 206003461
  
Corresponding Affymetrix probe sets: 1553982_a_at (Human Genome U133 Plus 2.0 Array)   230266_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000485468
Ensembl peptide - ENSP00000485563
Ensembl peptide - ENSP00000479762
Ensembl peptide - ENSP00000482499
Ensembl peptide - ENSP00000485386
NCBI entrez gene - 338382     See in Manteia.
RefSeq - XM_006711288
RefSeq - NM_001164522
RefSeq - NM_001304839
RefSeq - NM_177403
RefSeq Peptide - NP_001157994
RefSeq Peptide - NP_001291768
RefSeq Peptide - NP_796377
swissprot - A0A096LP44
swissprot - A0A096LPF0
swissprot - Q96AH8
Ensembl - ENSG00000276600
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAB7BENSGALG00000000769Gallus gallus
 Rab7bENSMUSG00000052688Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB7A / P51149 / RAB7A, member RAS oncogene familyENSG0000007578549
RAB9A / P51151 / RAB9A, member RAS oncogene familyENSG0000012359540
RAB9B / Q9NP90 / RAB9B, member RAS oncogene familyENSG0000012357040
RAB23 / Q9ULC3 / RAB23, member RAS oncogene familyENSG0000011221034
RAB32 / Q13637 / RAB32, member RAS oncogene familyENSG0000011850833
RAB38 / P57729 / RAB38, member RAS oncogene familyENSG0000012389232
RAB29 / O14966 / RAB29, member RAS oncogene familyENSG0000011728029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0034144 negative regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0034164 negative regulation of toll-like receptor 9 signaling pathway IEA
 biological_processGO:0034499 late endosome to Golgi transport IMP
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031902 late endosome membrane TAS
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
TBC/RABGAPs
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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