ENSMUSG00000007458


Mus musculus

Features
Gene ID: ENSMUSG00000007458
  
Biological name :M6pr
  
Synonyms : Cation-dependent mannose-6-phosphate receptor / M6pr / P24668
  
Possible biological names infered from orthology : mannose-6-phosphate receptor, cation dependent / P20645
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 122308720
Gene end: 122317680
  
Corresponding Affymetrix probe sets: 10541484 (MoGene1.0st)   1416385_a_at (Mouse Genome 430 2.0 Array)   1416386_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007602
Ensembl peptide - ENSMUSP00000108229
NCBI entrez gene - 17113     See in Manteia.
MGI - MGI:96904
RefSeq - NM_010749
RefSeq Peptide - NP_034879
swissprot - P24668
swissprot - Q3UKQ5
Ensembl - ENSMUSG00000007458
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 m6prENSDARG00000018432Danio rerio
 M6PRENSGALG00000031681Gallus gallus
 M6PRENSG00000003056Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000296  Cation-dependent mannose-6-phosphate receptor
 IPR009011  Mannose-6-phosphate receptor binding domain superfamily
 IPR028927  Mannose-6-phosphate receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0015761 mannose transmembrane transport IEA
 biological_processGO:0033299 secretion of lysosomal enzymes IDA
 cellular_componentGO:0000323 lytic vacuole IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005802 trans-Golgi network IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0015578 mannose transmembrane transporter activity IEA
 molecular_functionGO:1905394 retromer complex binding IEA


Pathways (from Reactome)
Pathway description
Lysosome Vesicle Biogenesis
Retrograde transport at the Trans-Golgi-Network
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6pr+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0003174 increased lysosomal enzyme secretion "production of glycoprotein hydrolytic enzymes is increased compared to normal" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm2(DTA)Riet/Gt(ROSA)26Sor+,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2tm1Rob,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm2Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Igf2tm1Rob/Igf2+,Igf2rtm1Arge/Igf2r+,M6prtm1Hlk/M6prtm1Hlk
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S/SvEv

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079316 Rab9 / Q9R0M6 / RAB9, member RAS oncogene family / RAB9A* / P51151* / RAB9A, member RAS oncogene family*  / complex
 ENSMUSG00000007458 M6pr / P24668 / Cation-dependent mannose-6-phosphate receptor / P20645* / mannose-6-phosphate receptor, cation dependent*  / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / complex
 ENSMUSG00000070953 Q8VCH5 / Rabepk / Rab9 effector protein with kelch motifs / Q7Z6M1*  / complex






 

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