ENSMUSG00000029428


Mus musculus

Features
Gene ID: ENSMUSG00000029428
  
Biological name :Stx2
  
Synonyms : Stx2 / syntaxin 2
  
Possible biological names infered from orthology : P32856
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G1.3
Gene start: 128984557
Gene end: 129008574
  
Corresponding Affymetrix probe sets: 10534041 (MoGene1.0st)   1418164_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142681
Ensembl peptide - ENSMUSP00000031378
Ensembl peptide - ENSMUSP00000098247
Ensembl peptide - ENSMUSP00000118220
NCBI entrez gene - 13852     See in Manteia.
MGI - MGI:108059
RefSeq - XM_006504276
RefSeq - NM_001286033
RefSeq - NM_001286034
RefSeq - NM_007941
RefSeq Peptide - NP_031967
RefSeq Peptide - NP_001272962
RefSeq Peptide - NP_001272963
swissprot - A0A0G2JE94
swissprot - D3YY94
swissprot - Q3TJ55
swissprot - Q80W45
Ensembl - ENSMUSG00000029428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stx2aENSDARG00000004618Danio rerio
 stx2bENSDARG00000068217Danio rerio
 STX2ENSGALG00000002536Gallus gallus
 STX2ENSG00000111450Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stx1b / P61264 / Syntaxin-1B / P61266*ENSMUSG0000003080663
Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*ENSMUSG0000000720763
Stx3 / Q64704 / Syntaxin-3 / Q13277*ENSMUSG0000004148861
Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*ENSMUSG0000003080543
Stx11 / syntaxin 11 / O75558*ENSMUSG0000003923230
Stx19 / Q8R1Q0 / Syntaxin-19 / Q8N4C7*ENSMUSG0000004785426
Gm379ENSMUSG0000009391622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR006011  Syntaxin, N-terminal domain
 IPR006012  Syntaxin/epimorphin, conserved site
 IPR010989  SNARE
 IPR028671  Syntaxin-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007340 acrosome reaction IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033194 response to hydroperoxide IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0061025 membrane fusion IEA
 biological_processGO:1903575 cornified envelope assembly IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 molecular_functionGO:0005484 SNAP receptor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tbx5tm1Jse/Tbx5+
Genetic Background: involves: 129S/SvEv

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Tbx5tm1Jse/Tbx5+
Genetic Background: involves: 129S/SvEv

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Stx2tm1Dcru/Stx2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0013955 increased colon length "increased length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0013957 increased small intestine length "increased length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0014081 branched small intestinal villi "atypical formation of branched tree-like structures in the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; branching may occur in association with increased or ectopic epithelial proliferation" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Ednrbtm1Myks/Ednrbtm1Myks
Genetic Background: involves: 129P2/OlaHsd

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Stx2repro34/Stx2repro34
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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