Manteia

ENSDARG00000070914

Danio rerio

Features

Gene ID:	ENSDARG00000070914

Biological name :	dusp6

Synonyms :	dual specificity phosphatase 6 / dusp6

Possible biological names infered from orthology :	Dual specificity protein phosphatase 6 / Q16828 / Q9DBB1

Species:	Danio rerio

Chr. number:	25
Strand:	-1
Band:
Gene start:	18326298
Gene end:	18330503

Corresponding Affymetrix probe sets:	Dr.16301.2.A1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000095269 NCBI entrez gene - 353314 See in Manteia. RefSeq - NM_194380 RefSeq Peptide - NP_919361 swissprot - Q7T2L8 ZFIN ID - ZDB-GENE-030613-1 Ensembl - ENSDARG00000070914

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DUSP6	ENSGALG00000011207	Gallus gallus
DUSP6	ENSG00000139318	Homo sapiens
Dusp6	ENSMUSG00000019960	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
dusp7 / dual specificity phosphatase 7 / Q16829*	ENSDARG00000101413	72
dusp8a / dual specificity phosphatase 8a / DUSP8* / Q13202* / O09112* / dual specificity phosphatase 8* / Dual specificity protein phosphatase 8 *	ENSDARG00000009299	30
dusp4 / dual specificity phosphatase 4 / Q13115* / Q8BFV3* / Dual specificity protein phosphatase 4 *	ENSDARG00000044688	29
dusp10 / dual specificity phosphatase 10 / Q9ESS0* / Q9Y6W6* / Dual specificity protein phosphatase 10 *	ENSDARG00000052465	27
dusp1 / dual specificity phosphatase 1 / P28562* / P28563* / Dual specificity protein phosphatase 1 *	ENSDARG00000100515	27
dusp16 / dual specificity phosphatase 16 / Q9BY84*	ENSDARG00000102474	26
dusp2 / dual specificity phosphatase 2 / Q05923*	ENSDARG00000098108	25
dusp5 / dual specificity phosphatase 5 / Q16690*	ENSDARG00000019307	25
si:dkey-175m17.7	ENSDARG00000078317	23
ssh2a / slingshot protein phosphatase 2a / SSH2* / Q5SW75* / Q76I76* / slingshot protein phosphatase 2* / Protein phosphatase Slingshot homolog 2 *	ENSDARG00000088440	22
ssh2b / slingshot protein phosphatase 2b / SSH2* / Q5SW75* / Q76I76* / slingshot protein phosphatase 2* / Protein phosphatase Slingshot homolog 2 *	ENSDARG00000098955	21
ssh1a / slingshot protein phosphatase 1a / SSH1* / Q76I79* / Q8WYL5* / slingshot protein phosphatase 1* / Protein phosphatase Slingshot homolog 1 *	ENSDARG00000056780	21
si:ch211-203d1.3 / SSH3* / Q8TE77* / Q8K330* / slingshot protein phosphatase 3* / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA.*	ENSDARG00000079591	20
ssh1b / slingshot protein phosphatase 1b / SSH1* / Q76I79* / Q8WYL5* / slingshot protein phosphatase 1* / Protein phosphatase Slingshot homolog 1 *	ENSDARG00000010031	19
si:ch211-195b15.8	ENSDARG00000094836	19

Protein motifs (from Interpro)

Interpro ID	Name
IPR000340	Dual specificity phosphatase, catalytic domain
IPR000387	Tyrosine specific protein phosphatases domain
IPR001763	Rhodanese-like domain
IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
IPR020422	Dual specificity protein phosphatase domain
IPR024950	Dual specificity phosphatase
IPR029021	Protein-tyrosine phosphatase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000188	inactivation of MAPK activity	IEA
biological_process	GO:0006470	protein dephosphorylation	IDA
biological_process	GO:0009953	dorsal/ventral pattern formation	IMP
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0016311	dephosphorylation	IEA
biological_process	GO:0035335	peptidyl-tyrosine dephosphorylation	IEA
biological_process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	IMP
biological_process	GO:0042663	regulation of endodermal cell fate specification	IGI
biological_process	GO:0043065	positive regulation of apoptotic process	IBA
biological_process	GO:0060420	regulation of heart growth	IBA
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IMP
molecular_function	GO:0004721	phosphoprotein phosphatase activity	IDA
molecular_function	GO:0004725	protein tyrosine phosphatase activity	IEA
molecular_function	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016787	hydrolase activity	IEA
molecular_function	GO:0016791	phosphatase activity	IMP
molecular_function	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	ISS

Pathways (from Reactome)

Pathway description

RAF-independent MAPK1/3 activation

ERKs are inactivated

Negative regulation of MAPK pathway

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000070573	mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*	/ reaction
ENSDARG00000023110	mapk7 / mitogen-activated protein kinase 7 / Q13164* / Q9WVS8*	/ reaction
ENSDARG00000027552	mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr