ENSGALG00000011207


Gallus gallus

Features
Gene ID: ENSGALG00000011207
  
Biological name :DUSP6
  
Synonyms : dual specificity protein phosphatase 6 / DUSP6
  
Possible biological names infered from orthology : dual specificity phosphatase 6 / Q16828 / Q9DBB1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 43288467
Gene end: 43292808
  
Corresponding Affymetrix probe sets: Gga.8445.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037562
NCBI entrez gene - 374272     See in Manteia.
RefSeq - NM_204354
RefSeq - XM_015277249
RefSeq Peptide - NP_989685
swissprot - A0A1D6UPT9
Ensembl - ENSGALG00000011207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp6ENSDARG00000070914Danio rerio
 DUSP6ENSG00000139318Homo sapiens
 Dusp6ENSMUSG00000019960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP7 / Gallus gallus dual specificity phosphatase 7 (DUSP7), mRNA. / Q16829* / Q91Z46* / dual specificity phosphatase 7* / Dual specificity protein phosphatase 7 *ENSGALG0000004165074
DUSP1 / dual specificity phosphatase 1 / P28562* / P28563* / Dual specificity protein phosphatase 1 *ENSGALG0000004036030
DUSP16* / Q9BY84* / dual specificity phosphatase 16*ENSGALG0000002815529
DUSP4 / dual specificity protein phosphatase 4 / Q13115* / Q8BFV3* / dual specificity phosphatase 4*ENSGALG0000001141929
DUSP8 / dual specificity phosphatase 8 / O09112* / Q13202* / Dual specificity protein phosphatase 8 *ENSGALG0000000664728
DUSP10 / dual specificity protein phosphatase 10 / Q9ESS0* / Q9Y6W6* / dual specificity phosphatase 10*ENSGALG0000000945028
DUSP5 / dual specificity phosphatase 5 / Q16690*ENSGALG0000003261826
SSH1 / slingshot protein phosphatase 1 / Q76I79* / Q8WYL5* / Protein phosphatase Slingshot homolog 1 *ENSGALG0000000492825
SSH2 / slingshot protein phosphatase 2 / Q5SW75* / Q76I76* / Protein phosphatase Slingshot homolog 2 *ENSGALG0000002157222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0051409 response to nitrosative stress IEA
 biological_processGO:0060420 regulation of heart growth IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction






 

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