ENSGALG00000011419


Gallus gallus

Features
Gene ID: ENSGALG00000011419
  
Biological name :DUSP4
  
Synonyms : dual specificity protein phosphatase 4 / DUSP4
  
Possible biological names infered from orthology : dual specificity phosphatase 4 / Q13115 / Q8BFV3
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 49691811
Gene end: 49696013
  
Corresponding Affymetrix probe sets: Gga.385.1.S1_at (Chicken Array)   Gga.6501.1.A1_at (Chicken Array)   GgaAffx.20379.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063821
Ensembl peptide - ENSGALP00000037153
NCBI entrez gene - 395642     See in Manteia.
RefSeq - NM_204838
RefSeq Peptide - NP_990169
swissprot - F1NCC5
swissprot - A0A1L1RY90
Ensembl - ENSGALG00000011419
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp4ENSDARG00000044688Danio rerio
 DUSP4ENSG00000120875Homo sapiens
 Dusp4ENSMUSG00000031530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP1 / dual specificity phosphatase 1 / P28562* / P28563* / Dual specificity protein phosphatase 1 *ENSGALG0000004036063
DUSP5 / dual specificity phosphatase 5 / Q16690*ENSGALG0000003261847
DUSP7 / Gallus gallus dual specificity phosphatase 7 (DUSP7), mRNA. / Q16829* / Q91Z46* / dual specificity phosphatase 7* / Dual specificity protein phosphatase 7 *ENSGALG0000004165031
DUSP6 / dual specificity protein phosphatase 6 / Q16828* / Q9DBB1* / dual specificity phosphatase 6*ENSGALG0000001120729
DUSP16* / Q9BY84* / dual specificity phosphatase 16*ENSGALG0000002815529
DUSP8 / dual specificity phosphatase 8 / O09112* / Q13202* / Dual specificity protein phosphatase 8 *ENSGALG0000000664728
DUSP10 / dual specificity protein phosphatase 10 / Q9ESS0* / Q9Y6W6* / dual specificity phosphatase 10*ENSGALG0000000945027
SSH1 / slingshot protein phosphatase 1 / Q76I79* / Q8WYL5* / Protein phosphatase Slingshot homolog 1 *ENSGALG0000000492825
SSH2 / slingshot protein phosphatase 2 / Q5SW75* / Q76I76* / Protein phosphatase Slingshot homolog 2 *ENSGALG0000002157223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:1990439 MAP kinase serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction






 

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