ENSG00000120875


Homo sapiens

Features
Gene ID: ENSG00000120875
  
Biological name :DUSP4
  
Synonyms : dual specificity phosphatase 4 / DUSP4 / Q13115
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p12
Gene start: 29333064
Gene end: 29350668
  
Corresponding Affymetrix probe sets: 204014_at (Human Genome U133 Plus 2.0 Array)   204015_s_at (Human Genome U133 Plus 2.0 Array)   226034_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000240100
Ensembl peptide - ENSP00000240101
NCBI entrez gene - 1846     See in Manteia.
OMIM - 602747
RefSeq - XM_011544428
RefSeq - NM_001394
RefSeq - NM_057158
RefSeq Peptide - NP_476499
RefSeq Peptide - NP_001385
swissprot - Q13115
Ensembl - ENSG00000120875
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp4ENSDARG00000044688Danio rerio
 DUSP4ENSGALG00000011419Gallus gallus
 Dusp4ENSMUSG00000031530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012960
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816645
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805041
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082930
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454529
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408628
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126628
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350727
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931827
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411223
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129821
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IDA
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IDA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:1990439 MAP kinase serine/threonine phosphatase activity IDA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction






 

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