ENSG00000143507


Homo sapiens

Features
Gene ID: ENSG00000143507
  
Biological name :DUSP10
  
Synonyms : dual specificity phosphatase 10 / DUSP10 / Q9Y6W6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q41
Gene start: 221701424
Gene end: 221742176
  
Corresponding Affymetrix probe sets: 215501_s_at (Human Genome U133 Plus 2.0 Array)   221563_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480008
Ensembl peptide - ENSP00000483812
Ensembl peptide - ENSP00000482935
Ensembl peptide - ENSP00000355866
NCBI entrez gene - 11221     See in Manteia.
OMIM - 608867
RefSeq - NM_007207
RefSeq Peptide - NP_009138
swissprot - A0A0B4J2F5
swissprot - Q9Y6W6
Ensembl - ENSG00000143507
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp10ENSDARG00000052465Danio rerio
 DUSP10ENSGALG00000009450Gallus gallus
 Dusp10ENSMUSG00000039384Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126623
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408622
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454522
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082922
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931822
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087522
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012921
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805020
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411219
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816618
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129818
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IDA
 biological_processGO:0002819 regulation of adaptive immune response IEA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IEA
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0030336 negative regulation of cell migration NAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IDA
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
 biological_processGO:0045088 regulation of innate immune response IEA
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0060266 negative regulation of respiratory burst involved in inflammatory response IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090335 regulation of brown fat cell differentiation IEA
 biological_processGO:1903753 negative regulation of p38MAPK cascade NAS
 biological_processGO:1905042 negative regulation of epithelium regeneration IEA
 biological_processGO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity IDA
 molecular_functionGO:0008432 JUN kinase binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0033549 MAP kinase phosphatase activity IEA
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IPI


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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