ENSG00000111266


Homo sapiens

Features
Gene ID: ENSG00000111266
  
Biological name :DUSP16
  
Synonyms : dual specificity phosphatase 16 / DUSP16 / Q9BY84
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.2
Gene start: 12474210
Gene end: 12562383
  
Corresponding Affymetrix probe sets: 1555399_a_at (Human Genome U133 Plus 2.0 Array)   1563505_at (Human Genome U133 Plus 2.0 Array)   224336_s_at (Human Genome U133 Plus 2.0 Array)   224832_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443039
Ensembl peptide - ENSP00000228862
Ensembl peptide - ENSP00000298573
Ensembl peptide - ENSP00000441250
NCBI entrez gene - 80824     See in Manteia.
OMIM - 607175
RefSeq - XM_017019988
RefSeq - XM_005253488
RefSeq - XM_006719155
RefSeq - XM_011520856
RefSeq - XM_011520857
RefSeq - NM_030640
RefSeq Peptide - NP_085143
swissprot - F5H5X4
swissprot - A0A024RAR2
swissprot - Q9BY84
Ensembl - ENSG00000111266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp16ENSDARG00000102474Danio rerio
 ENSGALG00000028155Gallus gallus
 Dusp16ENSMUSG00000030203Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454544
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129821
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411221
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087517
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931817
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408617
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012916
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350716
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816616
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805016
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283015
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation TAS
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0045204 MAPK export from nucleus TAS
 biological_processGO:0045209 MAPK phosphatase export from nucleus, leptomycin B sensitive TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity TAS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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