ENSMUSG00000030203


Mus musculus

Features
Gene ID: ENSMUSG00000030203
  
Biological name :Dusp16
  
Synonyms : dual specificity phosphatase 16 / Dusp16
  
Possible biological names infered from orthology : Q9BY84
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 134715468
Gene end: 134792625
  
Corresponding Affymetrix probe sets: 10548735 (MoGene1.0st)   1418401_a_at (Mouse Genome 430 2.0 Array)   1440615_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115925
Ensembl peptide - ENSMUSP00000144784
Ensembl peptide - ENSMUSP00000144834
Ensembl peptide - ENSMUSP00000098419
Ensembl peptide - ENSMUSP00000144917
NCBI entrez gene - 70686     See in Manteia.
MGI - MGI:1917936
RefSeq - NM_001048054
RefSeq - NM_130447
RefSeq Peptide - NP_001041519
RefSeq Peptide - NP_569714
swissprot - Q8BZE4
swissprot - A0A0N4SUV2
swissprot - A0A0N4SV20
swissprot - F6UIK0
swissprot - Q6PCP3
Ensembl - ENSMUSG00000030203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp16ENSDARG00000102474Danio rerio
 ENSGALG00000028155Gallus gallus
 DUSP16ENSG00000111266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788743
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792619
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212119
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153017
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371617
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996017
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736816
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938416
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419016
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461615
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476515
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation ISO
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016791 phosphatase activity ISO
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myo1gtm1.2Mfk/Myo1gtm1.2Mfk,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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