ENSMUSG00000019960


Mus musculus

Features
Gene ID: ENSMUSG00000019960
  
Biological name :Dusp6
  
Synonyms : Dual specificity protein phosphatase 6 / Dusp6 / Q9DBB1
  
Possible biological names infered from orthology : dual specificity phosphatase 6 / Q16828
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D1
Gene start: 99263231
Gene end: 99267489
  
Corresponding Affymetrix probe sets: 10366043 (MoGene1.0st)   1415834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151438
Ensembl peptide - ENSMUSP00000020118
NCBI entrez gene - 67603     See in Manteia.
MGI - MGI:1914853
RefSeq - NM_026268
RefSeq Peptide - NP_080544
swissprot - A0A1W2P715
swissprot - Q9DBB1
Ensembl - ENSMUSG00000019960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp6ENSDARG00000070914Danio rerio
 DUSP6ENSGALG00000011207Gallus gallus
 DUSP6ENSG00000139318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371670
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138355
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788730
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020330
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419029
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938429
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736828
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153028
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476527
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212125
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792624
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IBA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0040036 regulation of fibroblast growth factor receptor signaling pathway IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042663 regulation of endodermal cell fate specification IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0051409 response to nitrosative stress IEA
 biological_processGO:0060420 regulation of heart growth IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070848 response to growth factor IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IDA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity ISO


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000039 abnormal otic capsule morphology "malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000730 increased number of satellite cells "greater number of unfused cells in muscle that play a role in muscle regeneration" [J:42574]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Zp3-cre)93Knw/0,Zfp57tm1Xjli/Zfp57tm1Xjli
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * Black Swiss * C57BL/6J)

 MP:0030350 premature coronal suture closure "early closure of the coronal suture of the skull" [MGI:anna]
Show

Allelic Composition: Lmx1btm1Rjo/Lmx1btm1Zfc,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Dusp6tm1Sms/Dusp6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000001034 Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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