ENSMUSG00000034765


Mus musculus

Features
Gene ID: ENSMUSG00000034765
  
Biological name :Dusp5
  
Synonyms : dual specificity phosphatase 5 / Dusp5
  
Possible biological names infered from orthology : Q16690
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 53529109
Gene end: 53542431
  
Corresponding Affymetrix probe sets: 10463945 (MoGene1.0st)   1437199_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047900
NCBI entrez gene - 240672     See in Manteia.
MGI - MGI:2685183
RefSeq - NM_001085390
RefSeq Peptide - NP_001078859
swissprot - Q1HL35
Ensembl - ENSMUSG00000034765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp5ENSDARG00000019307Danio rerio
 DUSP5ENSGALG00000032618Gallus gallus
 DUSP5ENSG00000138166Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153047
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419043
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736838
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138330
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788727
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996027
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020327
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371627
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212124
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938423
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792622
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation ISO
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity ISO
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dusp5tm1.1Achn/Dusp5tm1.1Achn
Genetic Background: involves: C57BL/6NCrl

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp5tm1.1Achn/Dusp5tm1.1Achn,Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dusp5tm1.1Skey/Dusp5+
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dusp5tm1.1Achn/Dusp5tm1.1Achn
Genetic Background: involves: C57BL/6NCrl

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Dusp5tm1.1Achn/Dusp5tm1.1Achn
Genetic Background: involves: C57BL/6NCrl

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

Allelic Composition: Dusp5tm1d(KOMP)Wtsi/Dusp5tm1d(KOMP)Wtsi
Genetic Background: B6(Cg)-Dusp5tm1d(KOMP)Wtsi

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
Show

Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S7/SvEvBrd * FVB/N

 MP:0020184 altered susceptibility to parasitic infection "a change in the likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by a parasite" [GOC:NV]
Show

Allelic Composition: Dusp5tm1.1Achn/Dusp5tm1.1Achn
Genetic Background: involves: C57BL/6NCrl

Allelic Composition: Dusp5tm1.1Achn/Dusp5tm1.1Achn,Rag2tm1.1Cgn/Rag2tm1.1Cgn
Genetic Background: involves: C57BL/6NCrl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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