ENSMUSG00000024190


Mus musculus

Features
Gene ID: ENSMUSG00000024190
  
Biological name :Dusp1
  
Synonyms : Dual specificity protein phosphatase 1 / Dusp1 / P28563
  
Possible biological names infered from orthology : dual specificity phosphatase 1 / P28562
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 26505590
Gene end: 26508519
  
Corresponding Affymetrix probe sets: 10449284 (MoGene1.0st)   1448830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025025
NCBI entrez gene - 19252     See in Manteia.
MGI - MGI:105120
RefSeq - NM_013642
RefSeq Peptide - NP_038670
swissprot - P28563
swissprot - Q3U8K3
Ensembl - ENSMUSG00000024190
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp1ENSDARG00000100515Danio rerio
 DUSP1ENSGALG00000040360Gallus gallus
 DUSP1ENSG00000120129Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153065
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736846
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476545
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371631
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138331
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996030
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788729
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020329
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938427
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212126
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792624
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020417  Atypical dual specificity phosphatase
 IPR020420  Atypical dual specificity phosphatase, subfamily B
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity ISS
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation ISS
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0043409 negative regulation of MAPK cascade ISS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051447 negative regulation of meiotic cell cycle ISS
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071850 mitotic cell cycle arrest ISS
 biological_processGO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint ISS
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity ISO
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity ISS
 molecular_functionGO:0019838 growth factor binding IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0001573 abnormal circulating alanine transaminase level "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: C3.129S2-Dusp1tm1Brv

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0003360 depression-related behavior 
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myo5ad-l33J/Myo5ad-l33J
Genetic Background: involves: C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: C3.129S2-Dusp1tm1Brv

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: C3.129S2-Dusp1tm1Brv

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: C3.129S2-Dusp1tm1Brv

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009287 decreased abdominal fat pad weight "less than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp1tm1Blh/Bmp1tm1Blh,Tll1tm1Dgr/Tll1tm1Dgr
Genetic Background: involves: 129 * Black Swiss

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Phox2btm1(Phox2a)Mist/Phox2btm1(Phox2a)Mist
Genetic Background: involves: 129S4/SvJae

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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