ENSMUSG00000053716


Mus musculus

Features
Gene ID: ENSMUSG00000053716
  
Biological name :Dusp7
  
Synonyms : Dual specificity protein phosphatase 7 / Dusp7 / Q91Z46
  
Possible biological names infered from orthology : dual specificity phosphatase 7 / Q16829
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 106368632
Gene end: 106375724
  
Corresponding Affymetrix probe sets: 10588495 (MoGene1.0st)   1427416_x_at (Mouse Genome 430 2.0 Array)   1452097_a_at (Mouse Genome 430 2.0 Array)   1460393_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126984
Ensembl peptide - ENSMUSP00000133511
NCBI entrez gene - 235584     See in Manteia.
MGI - MGI:2387100
RefSeq - NM_153459
RefSeq Peptide - NP_703189
swissprot - G3UX16
swissprot - Q91Z46
Ensembl - ENSMUSG00000053716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp7ENSDARG00000101413Danio rerio
 DUSP7ENSGALG00000041650Gallus gallus
 DUSP7ENSG00000164086Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996064
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138350
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153027
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419027
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020327
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788727
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736826
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212125
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938425
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476524
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792621
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000001034 Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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