ENSG00000164086


Homo sapiens

Features
Gene ID: ENSG00000164086
  
Biological name :DUSP7
  
Synonyms : dual specificity phosphatase 7 / DUSP7 / Q16829
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.2
Gene start: 52048919
Gene end: 52056550
  
Corresponding Affymetrix probe sets: 213848_at (Human Genome U133 Plus 2.0 Array)   214793_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417183
Ensembl peptide - ENSP00000418566
NCBI entrez gene - 1849     See in Manteia.
OMIM - 602749
RefSeq - NM_001947
RefSeq Peptide - NP_001938
swissprot - Q16829
swissprot - H7C4Z0
Ensembl - ENSG00000164086
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp7ENSDARG00000101413Danio rerio
 DUSP7ENSGALG00000041650Gallus gallus
 Dusp7ENSMUSG00000053716Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931864
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082951
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087527
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454527
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126626
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816626
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350726
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805026
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012926
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411225
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129822
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IDA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
ERKs are inactivated
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000166484 MAPK7 / Q13164 / mitogen-activated protein kinase 7  / reaction






 

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