ENSG00000138166


Homo sapiens

Features
Gene ID: ENSG00000138166
  
Biological name :DUSP5
  
Synonyms : dual specificity phosphatase 5 / DUSP5 / Q16690
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.2
Gene start: 110497838
Gene end: 110511544
  
Corresponding Affymetrix probe sets: 209457_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358596
NCBI entrez gene - 1847     See in Manteia.
OMIM - 603069
RefSeq - NM_004419
RefSeq Peptide - NP_004410
swissprot - Q16690
Ensembl - ENSG00000138166
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp5ENSDARG00000019307Danio rerio
 DUSP5ENSGALG00000032618Gallus gallus
 Dusp5ENSMUSG00000034765Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087546
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012944
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805038
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082929
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931828
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126628
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408628
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454527
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411224
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350723
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129822
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IDA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction






 

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