ENSG00000120129


Homo sapiens

Features
Gene ID: ENSG00000120129
  
Biological name :DUSP1
  
Synonyms : dual specificity phosphatase 1 / DUSP1 / P28562
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.1
Gene start: 172768090
Gene end: 172771195
  
Corresponding Affymetrix probe sets: 201041_s_at (Human Genome U133 Plus 2.0 Array)   201044_x_at (Human Genome U133 Plus 2.0 Array)   226578_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000239223
NCBI entrez gene - 1843     See in Manteia.
OMIM - 600714
RefSeq - NM_004417
RefSeq Peptide - NP_004408
swissprot - P28562
Ensembl - ENSG00000120129
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp1ENSDARG00000100515Danio rerio
 DUSP1ENSGALG00000040360Gallus gallus
 Dusp1ENSMUSG00000024190Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087565
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816646
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805046
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408630
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931830
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454530
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082930
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126629
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350728
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411226
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129825
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity ISS
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006979 response to oxidative stress TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation ISS
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0043409 negative regulation of MAPK cascade ISS
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051447 negative regulation of meiotic cell cycle ISS
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071850 mitotic cell cycle arrest ISS
 biological_processGO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint ISS
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0004726 non-membrane spanning protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IDA
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity ISS
 molecular_functionGO:0019838 growth factor binding IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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