ENSG00000158050


Homo sapiens

Features
Gene ID: ENSG00000158050
  
Biological name :DUSP2
  
Synonyms : dual specificity phosphatase 2 / DUSP2 / Q05923
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q11.2
Gene start: 96143166
Gene end: 96145440
  
Corresponding Affymetrix probe sets: 204794_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000288943
NCBI entrez gene - 1844     See in Manteia.
OMIM - 603068
RefSeq - NM_004418
RefSeq - XM_017003546
RefSeq Peptide - NP_004409
swissprot - Q05923
Ensembl - ENSG00000158050
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp2ENSDARG00000098108Danio rerio
 Dusp2ENSMUSG00000027368Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012954
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087551
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816646
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931835
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408635
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082935
DUSP8 / Q13202 / dual specificity phosphatase 8ENSG0000018454533
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126633
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350731
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129827
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411226
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity TAS
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0031965 nuclear membrane IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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