ENSMUSG00000027368


Mus musculus

Features
Gene ID: ENSMUSG00000027368
  
Biological name :Dusp2
  
Synonyms : Dual specificity protein phosphatase 2 / Dusp2 / Q05922
  
Possible biological names infered from orthology : dual specificity phosphatase 2 / Q05923
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 127336159
Gene end: 127338376
  
Corresponding Affymetrix probe sets: 10475782 (MoGene1.0st)   1450698_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028846
NCBI entrez gene - 13537     See in Manteia.
MGI - MGI:101911
RefSeq - NM_010090
RefSeq Peptide - NP_034220
swissprot - Q05922
Ensembl - ENSMUSG00000027368
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp2ENSDARG00000098108Danio rerio
 DUSP2ENSG00000158050Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419053
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153050
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476546
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371634
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996034
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020333
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138333
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938431
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788731
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212126
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792626
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0001706 endoderm formation IBA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IDA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IPI


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
Show

Allelic Composition: Ncf4tm2Pth/Ncf4tm2Pth
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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