ENSMUSG00000037887


Mus musculus

Features
Gene ID: ENSMUSG00000037887
  
Biological name :Dusp8
  
Synonyms : Dual specificity protein phosphatase 8 / Dusp8 / O09112
  
Possible biological names infered from orthology : dual specificity phosphatase 8 / Q13202
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 142079490
Gene end: 142095843
  
Corresponding Affymetrix probe sets: 10569278 (MoGene1.0st)   10569280 (MoGene1.0st)   1418714_at (Mouse Genome 430 2.0 Array)   1428864_at (Mouse Genome 430 2.0 Array)   1447346_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049414
Ensembl peptide - ENSMUSP00000114307
NCBI entrez gene - 18218     See in Manteia.
MGI - MGI:106626
RefSeq - XM_011241989
RefSeq - NM_008748
RefSeq - XM_006508509
RefSeq Peptide - NP_032774
swissprot - O09112
swissprot - B7ZC52
Ensembl - ENSMUSG00000037887
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp8aENSDARG00000009299Danio rerio
 DUSP8ENSGALG00000006647Gallus gallus
 DUSP8ENSG00000184545Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020343
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792619
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212118
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996017
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371617
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153017
Dusp10 / Q9ESS0 / Dual specificity protein phosphatase 10 / Q9Y6W6* / dual specificity phosphatase 10*ENSMUSG0000003938416
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138316
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419016
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736815
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476515
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Olfr151tm40(Gnas*)Mom/Olfr151tm40(Gnas*)Mom
Genetic Background: B6;129P2-Olfr151tm40(Gnas*)Mom/MomJ

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Olfr151tm40(Gnas*)Mom/Olfr151tm40(Gnas*)Mom
Genetic Background: B6;129P2-Olfr151tm40(Gnas*)Mom/MomJ

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olfr151tm40(Gnas*)Mom/Olfr151tm40(Gnas*)Mom
Genetic Background: B6;129P2-Olfr151tm40(Gnas*)Mom/MomJ

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Olfr151tm40(Gnas*)Mom/Olfr151tm40(Gnas*)Mom
Genetic Background: B6;129P2-Olfr151tm40(Gnas*)Mom/MomJ

 MP:0010580 decreased heart left ventricle size "less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Olfr151tm40(Gnas*)Mom/Olfr151tm40(Gnas*)Mom
Genetic Background: B6;129P2-Olfr151tm40(Gnas*)Mom/MomJ

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Olfr151tm40(Gnas*)Mom/Olfr151tm40(Gnas*)Mom
Genetic Background: B6;129P2-Olfr151tm40(Gnas*)Mom/MomJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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