ENSG00000184545


Homo sapiens

Features
Gene ID: ENSG00000184545
  
Biological name :DUSP8
  
Synonyms : dual specificity phosphatase 8 / DUSP8 / Q13202
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 1554044
Gene end: 1571920
  
Corresponding Affymetrix probe sets: 206374_at (Human Genome U133 Plus 2.0 Array)   238594_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329539
Ensembl peptide - ENSP00000380530
NCBI entrez gene - 1850     See in Manteia.
OMIM - 602038
RefSeq - XM_011519933
RefSeq - NM_004420
RefSeq - XM_011519932
RefSeq Peptide - NP_004411
swissprot - Q13202
Ensembl - ENSG00000184545
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp8aENSDARG00000009299Danio rerio
 DUSP8ENSGALG00000006647Gallus gallus
 Dusp8ENSMUSG00000037887Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DUSP16 / Q9BY84 / dual specificity phosphatase 16ENSG0000011126647
SSH1 / Q8WYL5 / slingshot protein phosphatase 1ENSG0000008411220
SSH2 / Q76I76 / slingshot protein phosphatase 2ENSG0000014129820
DUSP7 / Q16829 / dual specificity phosphatase 7ENSG0000016408618
DUSP4 / Q13115 / dual specificity phosphatase 4ENSG0000012087518
DUSP1 / P28562 / dual specificity phosphatase 1ENSG0000012012918
DUSP6 / Q16828 / dual specificity phosphatase 6ENSG0000013931818
DUSP5 / Q16690 / dual specificity phosphatase 5ENSG0000013816617
DUSP9 / Q99956 / dual specificity phosphatase 9ENSG0000013082917
DUSP10 / Q9Y6W6 / dual specificity phosphatase 10ENSG0000014350717
SSH3 / Q8TE77 / slingshot protein phosphatase 3ENSG0000017283016
DUSP2 / Q05923 / dual specificity phosphatase 2ENSG0000015805016


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity ISS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation ISS
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity ISS
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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