ENSMUSG00000039384


Mus musculus

Features
Gene ID: ENSMUSG00000039384
  
Biological name :Dusp10
  
Synonyms : Dual specificity protein phosphatase 10 / Dusp10 / Q9ESS0
  
Possible biological names infered from orthology : dual specificity phosphatase 10 / Q9Y6W6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H5
Gene start: 184013302
Gene end: 184075636
  
Corresponding Affymetrix probe sets: 10352448 (MoGene1.0st)   1417163_at (Mouse Genome 430 2.0 Array)   1417164_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045838
Ensembl peptide - ENSMUSP00000121433
NCBI entrez gene - 63953     See in Manteia.
MGI - MGI:1927070
RefSeq - XM_006497189
RefSeq - NM_022019
RefSeq - XM_006497188
RefSeq Peptide - NP_071302
swissprot - Q9ESS0
swissprot - D3Z2S1
Ensembl - ENSMUSG00000039384
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dusp10ENSDARG00000052465Danio rerio
 DUSP10ENSGALG00000009450Gallus gallus
 DUSP10ENSG00000143507Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*ENSMUSG0000001996023
Dusp9 / dual specificity phosphatase 9 / Q99956*ENSMUSG0000003138322
Dusp8 / O09112 / Dual specificity protein phosphatase 8 / Q13202* / dual specificity phosphatase 8*ENSMUSG0000003788722
Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*ENSMUSG0000003153022
Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*ENSMUSG0000005371622
Dusp16 / dual specificity phosphatase 16 / Q9BY84*ENSMUSG0000003020322
Dusp1 / P28563 / Dual specificity protein phosphatase 1 / P28562* / dual specificity phosphatase 1*ENSMUSG0000002419021
Dusp2 / Q05922 / Dual specificity protein phosphatase 2 / Q05923* / dual specificity phosphatase 2*ENSMUSG0000002736820
Dusp5 / dual specificity phosphatase 5 / Q16690*ENSMUSG0000003476519
Ssh1 / Q76I79 / Protein phosphatase Slingshot homolog 1 / Q8WYL5* / slingshot protein phosphatase 1*ENSMUSG0000004212119
Ssh2 / Q5SW75 / Protein phosphatase Slingshot homolog 2 / Q76I76* / slingshot protein phosphatase 2*ENSMUSG0000003792618
Ssh3 / Q8K330 / Mus musculus slingshot protein phosphatase 3 (Ssh3), transcript variant 2, mRNA. / Q8TE77* / slingshot protein phosphatase 3*ENSMUSG0000003461615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR001763  Rhodanese-like domain
 IPR008343  Mitogen-activated protein (MAP) kinase phosphatase
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR020417  Atypical dual specificity phosphatase
 IPR020422  Dual specificity protein phosphatase domain
 IPR024950  Dual specificity phosphatase
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000188 inactivation of MAPK activity IEA
 biological_processGO:0002819 regulation of adaptive immune response IMP
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IMP
 biological_processGO:0016311 dephosphorylation ISO
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IMP
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
 biological_processGO:0045088 regulation of innate immune response IMP
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0060266 negative regulation of respiratory burst involved in inflammatory response IMP
 biological_processGO:0070303 negative regulation of stress-activated protein kinase signaling cascade ISO
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0090335 regulation of brown fat cell differentiation IDA
 biological_processGO:1903753 negative regulation of p38MAPK cascade IEA
 biological_processGO:1905042 negative regulation of epithelium regeneration IDA
 biological_processGO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity ISO
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0008330 protein tyrosine/threonine phosphatase activity IEA
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity ISO
 molecular_functionGO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0033549 MAP kinase phosphatase activity IDA
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Cckartm1Kpn/Cckartm1Kpn
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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